Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May;41(2):205-219.
doi: 10.1016/j.iac.2021.01.008. Epub 2021 Mar 24.

Tackling Food Allergy in Infancy

Ashley Lynn Devonshire  1 , Adora A Lin  2
Affiliations
Review

Tackling Food Allergy in Infancy

Ashley Lynn Devonshire et al. Immunol Allergy Clin North Am. 2021 May.

Abstract

Atopic dermatitis and food allergy are the most common allergic conditions affecting the infant population. Both immunoglobulin E (IgE)-mediated and non-IgE-mediated food allergy are seen in infancy. Early life feeding guidelines have changed dramatically over the past 30 years, more recently because of an improved understanding of IgE-mediated food allergy. This article focuses on identification, diagnosis, management, and prevention of food allergy in the infant population.

Keywords: Atopic dermatitis; Food allergy; Infancy; Oral food challenge; Prevention.

PubMed Disclaimer

Conflict of interest statement

Disclosure A.L. Devonshire does not have any commercial or financial conflicts of interest. A.L. Devonshire is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH), under Award Number 5KL2TR001426-04. A.A. Lin does not have any commercial or financial conflicts of interest. A.A. Lin is supported by the American Academy of Allergy, Asthma, and Immunology Foundation and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, under Award Number K23 AI153543-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Figures

Figure 1.
Figure 1.
Algorithm proposed for approach to patients with moderate-severe AD and concern about potential food trigger. From Bergmann MM et al. Evaluation of food allergy in patients with atopic dermatitis. J Allergy Clin Immunol Pract. 2013;1(1):25; with permission. (Figure 1 in original)
Figure 2.
Figure 2.
Algorithm proposed for approach to infants with an adverse food reaction following breastfeeding. From Rajani PS et al. Presentation and Management of Food Allergy in Breastfed Infants and Risks of Maternal Elimination Diets. J Allergy Clin Immunol Pract. 2020;8(1):61; with permission. (Figure 2 in original)
Figure 3.
Figure 3.
Status of interventions for the primary prevention of food allergy in infancy. From Bird JA et al. Prevention of food allergy: Beyond peanut. J Allergy Clin Immunol. 2019;143(2):546; with permission. (Figure 1 in original)
See this image and copyright information in PMC

References

    1. Bock SA, Atkins FM. Patterns of food hypersensitivity during sixteen years of double-blind, placebo-controlled food challenges. J Pediatr. 1990;117(4):561–567. - PubMed
    1. Bruijnzeel-Koomen C, Ortolani C, Aas K, et al. Adverse reactions to food. European Academy of Allergology and Clinical Immunology Subcommittee. Allergy. 1995;50(8):623–635. - PubMed
    1. Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113(5):832–836. - PubMed
    1. Sackeyfio A, Senthinathan A, Kandaswamy P, et al. Diagnosis and assessment of food allergy in children and young people: summary of NICE guidance. BMJ. 2011;342:d747. - PubMed
    1. Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol. 2010;126(6):1105–1118. - PMC - PubMed

Publication types

Substances