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Comment
. 2021 Apr 16;6(1):156.
doi: 10.1038/s41392-021-00587-3.

COVID-19: complexity of disease severity revealed by systemic and localized single cell immune atlas

Affiliations
Comment

COVID-19: complexity of disease severity revealed by systemic and localized single cell immune atlas

Nehad M Alajez. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Schematic presentation of altered immune subsets in the periphery and lungs from COVID-19 patients. Frequencies of immune subsets in the circulation (a) and lung tissue (b) from patients with COVID-19. ↑ indicates increased while ↓ indicates decreased frequencies

Comment on

  • COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.
    Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Jiang C, Liang J, Li YM, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu SQ, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zuo Z, Bai F, Huang X, Zhou P, Jiang Q, Huang Z, Bei JX, Wei L, Bian XW, Liu X, Cheng T, Li X, Zhao P, Wang FS, Wang H, Su B, Zhang Z, Qu K, Wang X, Chen J, Jin R, Zhang Z. Ren X, et al. Cell. 2021 Apr 1;184(7):1895-1913.e19. doi: 10.1016/j.cell.2021.01.053. Epub 2021 Feb 3. Cell. 2021. PMID: 33657410 Free PMC article.

References

    1. Ren X, et al. COVID-19 immune features revealed by a large-scale single cell transcriptome atlas. Cell. 2021;184:1895–1913.e19. doi: 10.1016/j.cell.2021.01.053. - DOI - PMC - PubMed
    1. Zhang JY, et al. Single-cell landscape of immunological responses in patients with COVID-19. Nat. Immunol. 2020;21:1107–1118. doi: 10.1038/s41590-020-0762-x. - DOI - PubMed
    1. Shaath H, Vishnubalaji R, Elkord E, Alajez NM. Single-cell transcriptome analysis highlights a role for neutrophils and inflammatory macrophages in the pathogenesis of severe COVID-19. Cells. 2020;9:2374. doi: 10.3390/cells9112374. - DOI - PMC - PubMed
    1. Wilk AJ, et al. A single-cell atlas of the peripheral immune response in patients with severe COVID-19. Nat. Med. 2020;26:1070–1076. doi: 10.1038/s41591-020-0944-y. - DOI - PMC - PubMed

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