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. 2021 Apr 16;11(1):8362.
doi: 10.1038/s41598-021-87014-3.

Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

Konstantin N Semenov  1   2   3 , Daria A Ivanova  4 , Sergei V Ageev  4   5 , Andrey V Petrov  5 , Nikita E Podolsky  5 , Ekaterina M Volochaeva  6 , Ekaterina M Fedorova  6 , Anatolii A Meshcheriakov  4   5 , Egor E Zakharov  4 , Igor V Murin  5 , Vladimir V Sharoyko  7   8   9
Affiliations

Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

Konstantin N Semenov et al. Sci Rep. .

Abstract

The article is devoted to the study of the pharmacokinetics of fullerene C60 in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C60 was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C60 in the micellar form is higher than that in an oil solution.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
13C NMR spectrum of C60 obtained with CP/MAS technique.
Figure 2
Figure 2
MALDI mass spectrum of C60 fullerene.
Figure 3
Figure 3
IR spectrum of C60 fullerene.
Figure 4
Figure 4
A chemical structure of TWEEN-80.
Figure 5
Figure 5
Size distribution of a C60 micellar form.
Figure 6
Figure 6
Absorption spectrum of fullerene C60 in olive oil.
Figure 7
Figure 7
Triglyceride molecule consisting of two oleic acid residues and one palmitic acid residue.
Figure 8
Figure 8
Cell with fullerene molecule and 20 triglyceride molecules.
Figure 9
Figure 9
HPLC–MS chromatogram of C60.
Figure 10
Figure 10
Solubility polytherm of fullerene C60 in olive oil in the temperature range 0–80 °C.
Figure 11
Figure 11
A density field of oleic residues in a system under study.
Figure 12
Figure 12
Pharmacokinetics of fullerene C60 in whole blood after oral administration to mice of an oil solution (–■–) and micellar form of fullerene C60 (–●–). Dots are experimental points; lines represent Eq. 2.
See this image and copyright information in PMC

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