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Comment
. 2021 Jul;18(7):1626-1627.
doi: 10.1038/s41423-021-00677-w. Epub 2021 Apr 16.

Disease tolerance to infection: the immune defense strategy of mitoribosome targeting

Lawrence Shih-Hsin Wu  1 , Jiu-Yao Wang  2   3
Affiliations
Comment

Disease tolerance to infection: the immune defense strategy of mitoribosome targeting

Lawrence Shih-Hsin Wu et al. Cell Mol Immunol. 2021 Jul.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Doxycycline targets mitoribosomes and introduces mild stress to mitochondria to increase disease tolerance for sepsis. Doxycycline blocks aminoacyl-tRNA (aa-tRNA) to the A site of the mitoribosome to inhibit the translation of mitochondria-encoded genes. Mild perturbation of mitochondria was induced by inhibition of mitochondrial protein synthesis and presented as reduced activity of the electron transport chains (ETC). ETC perturbation can trigger compensatory cytoprotective responses, such as decreased lipid accumulation
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