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. 2021 May;35(5):1485-1489.
doi: 10.1038/s41375-021-01242-0. Epub 2021 Apr 16.

Single base substitution mutational signatures in pediatric acute myeloid leukemia based on whole genome sequencing

Rebeqa Gunnarsson #  1 , Minjun Yang #  2 , Linda Olsson-Arvidsson  2   3 , Andrea Biloglav  2 , Mikael Behrendtz  4 , Anders Castor  5 , Kajsa Paulsson  2 , Bertil Johansson  2   3
Affiliations

Single base substitution mutational signatures in pediatric acute myeloid leukemia based on whole genome sequencing

Rebeqa Gunnarsson et al. Leukemia. 2021 May.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Overview of the transition and transversion types and the single base substitution (SBS) mutational signatures in the pediatric acute myeloid leukemias cases.
Left panel: the distribution of the six different transition and transversion types per case. Middle panel: heat map showing the distribution of the SBS signatures in each case. Right panel: The frequencies of the five overall most common signatures (SBS1, SBS18, SBS32, SBS37, and SBS39) per case.
Fig. 2
Fig. 2. Overview of gene ontology (GO)-annotated molecular functions of the 43 genes with pathogenic variants.
A–N indicate different GO functions: A metal ion binding; B nucleotide binding; C metal ion and nucleotide binding; D chromatin binding; E metal ion and chromatin binding; F chromatin and polymerase II activating transcription factor binding; G metal ion, chromatin/DNA binding, and transcription activator; H chromatin/DNA binding and transcription activator; I metal ion, DNA binding, and transcription activator; J metal ion, DNA and RNA polymerase II activating transcription factor binding, and transcription activator; K metal ion binding and helicase activity; L helicase activity; M metal ion binding and cytoskeletal protein binding; N cytoskeletal protein binding.
See this image and copyright information in PMC

References

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