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Randomized Controlled Trial
. 2021 Nov;40(11):2411-2419.
doi: 10.1007/s10096-021-04241-2. Epub 2021 Apr 16.

Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial

Dolors Rodríguez-Pardo  1   2   3 , María Dolores Del Toro  4   5   6 , Laura Guío-Carrión  4   5   7 , Rosa Escudero-Sánchez  5   8 , Marta Fernández-Sampedro  4   5   9 , Miguel Ángel García-Viejo  5   10 , María Velasco-Arribas  5   11 , Laura Soldevila-Boixader  5   12 , Magdalena Femenias  13 , José Antonio Iribarren  5   14 , María Del Carmen Pulido-Garcia  15 , María Dolores Navarro  4   5   6 , Mayli Lung  4   5   16 , Pablo S Corona  4   5   17 , Benito Almirante  18   4   5 , Carles Pigrau  18   4   5
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Free article
Randomized Controlled Trial

Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial

Dolors Rodríguez-Pardo et al. Eur J Clin Microbiol Infect Dis. 2021 Nov.
Free article

Abstract

Purpose: To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture.

Methods: Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB.

Primary outcome: early-PJI after HHA.

Results: Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin-trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33-3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15-7.10]).

Conclusions: Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47.

Keywords: Asymptomatic bacteriuria; Early-periprosthetic joint infection; Fosfomycin-trometamol; Hip hemiarthroplasty.

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References

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