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. 2021 Dec;76(12):3713-3722.
doi: 10.1111/all.14862. Epub 2021 May 3.

Neonatal airway immune profiles and asthma and allergy endpoints in childhood

Bo L Chawes  1 , Helene M Wolsk  1 , Christian J Carlsson  1 , Morten A Rasmussen  1   2 , Nilofar Følsgaard  1 , Jakob Stokholm  1 , Klaus Bønnelykke  1 , Susanne Brix  3 , Ann-Marie M Schoos  1 , Hans Bisgaard  1
Affiliations

Neonatal airway immune profiles and asthma and allergy endpoints in childhood

Bo L Chawes et al. Allergy. 2021 Dec.

Abstract

Background: The immune system plays a key role in the pathogenesis of asthma and allergy, but the role of the airway cytokine and chemokine composition in vivo in early life prior to symptom development has not been described previously. Here, we aimed to examine whether the neonatal airway immune composition associates with development of allergy and asthma in childhood.

Methods: We measured unstimulated levels of 20 immune mediators related to the Type 1, Type 2, Type 17, or regulatory immune pathways in the airway mucosal lining fluid of 620 one-month-old healthy neonates from the COPSAC2010 birth cohort. Allergy and asthma were diagnosed at our research clinic by predefined algorithms and objective assessments at age 6 years. Principal component analyses were used to describe the airway cytokine and chemokine composition.

Results: A neonatal airway immune profile particularly characterized by enhanced IL-1β and reduced CCL26 was significantly associated with later development of elevated specific IgE to inhaled allergens, a positive skin prick test, and allergic rhinitis, but not with food sensitization. Conversely, reduced Type 17 immune-associated markers, including IL-1β and CXCL8, showed trend of association with development of early asthma endpoints.

Conclusions: Development of early asthma endpoints and inhalant allergy during the first 6 years of life seems associated with distinctly perturbed airway immune profiles in neonatal life, which is suggestive of an early origin and different pathogenesis of childhood asthma and allergy. These exploratory findings suggest pre- and perinatal life as an important window of opportunity for prevention of asthma and inhalant allergy.

Keywords: allergy; asthma; chemokines; children; cytokines.

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References

REFERENCES

    1. Illi S, Weber J, Zutavern A, et al. Perinatal influences on the development of asthma and atopy in childhood. Ann Allergy Asthma Immunol. 2014;112(2):132-139.e1.
    1. Ege MJ, Mayer M, Normand A-C, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364:701-709.
    1. Følsgaard NV, Chawes BLK, Bønnelykke K, Jenmalm MC, Bisgaard H. Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age. Clin Exp Allergy. 2012;42:1596-1603.
    1. Sandberg M, Frykman A, Ernerudh J, et al. Cord blood cytokines and chemokines and development of allergic disease. Pediatr Allergy Immunol. 2009;20:519-527.
    1. Juntti H, Österlund P, Kokkonen J, et al. Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection. J Aller Clin Immunol. 2009;124(1):52-58.e2.

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