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Meta-Analysis
. 2021 Sep;35(9):4930-4942.
doi: 10.1002/ptr.7122. Epub 2021 Apr 17.

Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies

Affiliations
Meta-Analysis

Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies

Júlio César Moreira Brito et al. Phytother Res. 2021 Sep.

Abstract

Viral infections of the lower respiratory tract are considered a public health problem. They affect millions of people worldwide, causing thousands of deaths, and are treated with expensive medicines, such as antivirals or palliative measures. In this study, we conducted a systematic review to describe the use of quercetin-type flavonols against lower respiratory tract viruses and discussed the preclinical impact of this approach on different signs and clinical mechanisms of infection. The systematic review was performed in PubMed/MEDLINE, Scopus, Scielo, and Biblioteca Virtual de Saúde (BVS). After the database search, 11 relevant studies were identified as eligible. The analysis of these studies showed evidence of antiviral activity of quercetin-type flavonols with significantly reduced mortality rate (M-H = 0.19, 95% CI: 0.05 to 0.65, p-value = 0.008) of infected animals and a reduction in the average viral load (IV = -1.93, 95% CI: -3.54 to -0.31, p-value = 0.02). Additionally, quercetin and its derivatives reduced the amount of proinflammatory cytokines, chemokines, reactive oxygen species, mucus production, and airway resistance in animals infected with a respiratory virus. Overall, supplementation with quercetin-type flavonols is a promising strategy for treating viral-induced lower respiratory tract infections.

Keywords: chemoprophylaxis; flavonoids; influenza virus; quercetin; rhinovirus; virus-induced lower respiratory tract infections.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the selection of articles for systematic review according to the PRISMA criteria
FIGURE 2
FIGURE 2
Meta‐analysis of the mortality in animals with virus‐induced lower respiratory tract infections treated with quercetin‐type flavonols
FIGURE 3
FIGURE 3
Meta‐analysis of the pulmonary viral load in animals with virus‐induced lower respiratory tract infections treated with quercetin‐type flavonols
FIGURE 4
FIGURE 4
Chemical structure of quercetin and its glycosylated (rutin, isoquercetin, and quercetin‐3‐O‐β‐D‐glucuronide) and nonglycosylated (quercetin and isorhamnetin) derivatives
FIGURE 5
FIGURE 5
Schematic summary of the clinical activity of quercetin‐type flavonols in animals with virus‐induced lower respiratory tract infections

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References

    1. Álvarez, P. , Alvarado, C. , Puerto, M. , Schlumberger, A. , Jiménez, L. , & De la Fuente, M. (2006). Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol‐rich cereals. Nutrition, 22(9), 913–921. 10.1016/j.nut.2005.12.012 - DOI - PubMed
    1. Anand David, A. V. , Arulmoli, R. , & Parasuraman, S. (2016). Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacognosy Reviews, 10(20), 84–89. 10.4103/0973-7847.194044 - DOI - PMC - PubMed
    1. Batiha, G. E. , Beshbishy, A. M. , Ikram, M. , Mulla, Z. S. , Abd El‐Hack, M. E. , Taha, A. E. , … Ali Elewa, Y. H. (2020). The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: Quercetin. Foods, 9(3), 374. 10.3390/foods9030374 - DOI - PMC - PubMed
    1. Benton, D. J. , Nans, A. , Calder, L. J. , Turner, J. , Neu, U. , Lin, Y. P. , … Skehel, J. J. (2018). Influenza hemagglutinin membrane anchor. Proceedings of the National Academy of Sciences of the United States of America, 115(40), 10112–10117. 10.1073/pnas.1810927115 - DOI - PMC - PubMed
    1. Bentz, A. B. (2017). A review of quercetin: Chemistry, antioxidant properties, and bioavailability. Journal of Young Investigators. Retrieved from https://www.jyi.org/2009‐april/2017/10/15/a‐review‐of‐quercetin‐chemistr...

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