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Editorial
. 2021 Jul;69(7):1811-1814.
doi: 10.1111/jgs.17160. Epub 2021 Apr 17.

The other striated muscle: The role of sarcopenia in older persons with heart failure

Gordon R Reeves  1 , Ambarish Pandey  2 , Dalane W Kitzman  3
Affiliations
Editorial

The other striated muscle: The role of sarcopenia in older persons with heart failure

Gordon R Reeves et al. J Am Geriatr Soc. 2021 Jul.
No abstract available

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Conflict of interest statement

Ambarish Pandey has served on the advisory board of Roche Diagnostics. Dalane W. Kitzman reported receiving honoraria outside the present study as a consultant for Bayer, Merck, Medtronic, Relypsa, Merck, Corvia Medical, Boehringer-Ingelheim, NovoNordisk, Astra Zeneca, and Novartis, and grant funding outside the present study from Novartis, Bayer, NovoNordisk, and Astra Zeneca, and stock ownership in Gilead Sciences.

Figures

FIGURE 1
FIGURE 1
Sarcopenia in heart failure—prevalence, risk factors, and potential therapeutic strategies. Sarcopenia is common in patients with heart failure and worsened by decompensated heart failure hospitalization. Risk factors such as comorbidities, physical inactivity, malnutrition, upregulation of inflammatory pathways, insulin resistance, and neurohormonal activation contribute to the development of sarcopenia in patients with heart failure. Therapeutic approaches such as exercise training, improved nutritional support, and some potential pharmacotherapies (ghrelin analogues and selective androgen receptor modulators) may improve sarcopenia in patients with heart failure
See this image and copyright information in PMC

Comment on

References

    1. Cheng RK, Cox M, Neely ML, et al. Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population. Am Heart J. 2014;168(5):721–730. - PubMed
    1. Upadhya B, Pisani B, Kitzman DW. Evolution of a geriatric syndrome: pathophysiology and treatment of heart failure with preserved ejection fraction. J Am Geriatr Soc. 2017;65(11):2431–2440. - PMC - PubMed
    1. Kitzman D, Haykowsky M, Tomczak C. Making the case for skeletal muscle myopathy and its contribution to exercise intolerance in heart failure with preserved ejection fraction. Circ Heart Fail. 2017;10:e004281. - PMC - PubMed
    1. Attaway A, Bellar A, Dieye F, Wajda D, Welch N, Dasarathy S. Clinical impact of compound sarcopenia in hospitalized older adult patients with heart failure. J American Geriatr Soc. 2021;69(7):1815–1825. 10.1111/jgs.17108 - DOI - PMC - PubMed
    1. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31. - PMC - PubMed