Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2021 Aug-Sep;53(7):102053.
doi: 10.1016/j.aprim.2021.102053. Epub 2021 Apr 14.

[Long-term effect analysis of a cognitive stimulation program in mild cognitive impairment elderly in Primary Care: A randomized controlled trial]

[Article in Spanish]
Isabel Gómez-Soria  1 , Eva María Andrés Esteban  2 , Alejandro Gómez Bruton  3 , Patricia Peralta-Marrupe  4
Affiliations
Randomized Controlled Trial

[Long-term effect analysis of a cognitive stimulation program in mild cognitive impairment elderly in Primary Care: A randomized controlled trial]

[Article in Spanish]
Isabel Gómez-Soria et al. Aten Primaria. 2021 Aug-Sep.

Abstract
in English, Spanish

Objective: To provide evidence about the efficacy of a community health intervention through a cognitive stimulation program at long term in older people with mild cognitive impairment.

Design: Randomized controlled trial (CONSORT group norms).

Location: San José Norte-Centro Primary Care Center and La Caridad Foundation (Zaragoza, Spain).

Participants: Twenty-nine people over 65 years old with a 24-27 MEC score that completed 48 months follow up. They were randomized between the intervention group (15) and the control group (14).

Interventions: The intervention was applied in 10 sessions of 45min for 10 weeks using the red notebook tool for mental activation that works memory, orientation, language, praxis, gnosis, calculation, perception, logical reasoning, attention and executive functions.

Main measurements: The main outcome variables were MEC-35, Set-test, Barthel index, Lawton-Brody scale, Goldberg anxiety scale and Yesavage geriatric depression scale short form.

Results: Increases of the main result variable over the baseline level of MEC-35 were analyzed. On average, the intervention group obtained higher scores than control: 3.14 points post intervention, 3.76 points after 6 months and 2.26 points more than control group after 12 months. All the differences were statistically significant. After 48 months the intervention group obtained 2 points more than control group. The intervention did not improve verbal fluency, activity daily living and mood.

Conclusions: Our cognitive stimulation program seems to improve cognitive performance, measured with the variable MEC-35 at post intervention, 6, 12 and 48 months. There is no evidence of improvement in verbal fluency, activity daily livings and mood. Clinicaltrials.gov Identifier: NCT03831061.

Objetivo: Aportar evidencias de la eficacia de una intervención comunitaria en salud a través de un programa de estimulación cognitiva (PEC) implementada con el paso del tiempo en mayores con deterioro cognitivo leve en la comunidad.

Diseño: Seguimiento de un ensayo controlado aleatorizado (normas grupo CONSORT).

Emplazamiento: Centro de salud San José Norte-Centro y Fundación La Caridad (Zaragoza).

Participantes: Veintinueve personas ≥ 65 años, con 24-27 puntos en el MEC-35 que completaron el ensayo a los 48 meses, 15 aleatorizados en el grupo intervención y 14 en el grupo control.

Intervenciones: Se realizaron 10 sesiones, 45 min/semana, durante 10 semanas, con el cuaderno rojo de activación mental que ejercita: memoria, orientación, lenguaje, praxis, gnosis, cálculo, percepción, razonamiento lógico, atención y funciones ejecutivas.

Mediciones principales: MEC-35, Set-test, Barthel, Lawton-Brody, subescala de ansiedad Goldberg y Yesavage abreviado (GDS-15).

Resultados: Analizando los incrementos sobre el nivel basal para MEC-35, el grupo intervención obtiene, de media: postintervención 3,14 puntos, a los 6 meses 3,76 puntos y a los 12 meses 2,26 puntos más que el grupo control, siendo estos incrementos estadísticamente significativos. A los 48 meses el grupo intervención sigue obteniendo 2 puntos más que el control, sin ser significativos. La intervención no mejoró el desempeño en fluidez verbal, actividades de la vida diaria ni estado de ánimo.

Conclusiones: Nuestro PEC podría ser eficaz en la mejora de la cognición general, medida con el MEC-35, en postintervención, a los 6, 12 y 48 meses. No se evidencian mejoras en fluidez verbal, actividades de la vida diaria ni estado de ánimo.

Clinicaltrials.gov Identifier: NCT03831061.

Keywords: Aging; Cognitive stimulation; Deterioro cognitivo leve; Ensayo controlado aleatorizado; Envejecimiento; Estimulación cognitiva; Mild cognitive impairment; Non-pharmacological therapies; Occupational therapy; Randomized controlled trial; Terapia ocupacional; Terapias no farmacológicas.

PubMed Disclaimer

Figures

Figura 1
Figura 1
Diagrama de flujo de los participantes.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Youn J.H., Park S., Lee J.Y., Cho S.J., Ryu S.H. Cognitive improvement in older adults with mild cognitive impairment: evidence from a multi-strategic metamemory training. J Clin Med. 2020;9:362. doi: 10.3390/jcm9020362. - DOI - PMC - PubMed
    1. Gauthier S., Reisberg B., Zaudig M., Petersen R.C., Ritchie K., Broich K. Mild cognitive impairment. Lancet. 2006;367:1262–1269. doi: 10.1016/S0140-6736(06)68542-5. - DOI - PubMed
    1. Olazaran J. ¿Puede diagnosticarse la demencia en la atención primaria? Aten Primaria. 2011;43:377–384. doi: 10.1016/j.aprim.2010.09.004. - DOI - PMC - PubMed
    1. Argimón Pallàs J.M., Riu Subirana S., Lizán Tudela L., Badia Llach X., Martínez Lage J.M. Tratamiento inicial de los pacientes con quejas subjetivas de memoria o deterioro cognitivo en atención primaria: estudio ISSEA. Aten Primaria. 2007;39:171–179. - PMC - PubMed
    1. Petersen R.C. Mild cognitive impairment. Continuum (Minneap Minn). 2016;22:404–418. - PMC - PubMed

Publication types

Associated data