Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;55(1):18-27.
doi: 10.15644/asc55/1/3.

Caries Preventive Effects of Theobromine Containing Toothpaste on Early Childhood Caries: Preliminary Results

Muesser Ahu Durhan  1 , Seda Ozsalih  1 , Berna Gokkaya  2 , Pinar Yildiz Kulan  1 , Betul Kargul  1
Affiliations

Caries Preventive Effects of Theobromine Containing Toothpaste on Early Childhood Caries: Preliminary Results

Muesser Ahu Durhan et al. Acta Stomatol Croat. 2021 Mar.

Abstract

Objective: Enamel remineralizing effects of theobromine have received much attention from the clinicians. The aim of this study was to investigate the caries preventive effect of theobromine containing toothpaste on children with early childhood caries (ECC).

Material and methods: Salivary pH, buffering capacity and frequency of Streptococcus mutans (SM) levels were measured. Each child was assigned either fluoridated or theobromine containing toothpaste. The changes were analyzed using Laser Fluorescence system. Statistical analyses were performed.

Results: We included 13 children (mean age 4.25) with 145 teeth in the fluoridated toothpaste (Colgate Kids toothpaste) group; 13 children (mean age 4.46) with 115 teeth in theobromine containing toothpaste (TheodentTMKids toothpaste) group. Both toothpastes demonstrated enamel remineralization and were effective in increasing the buffering capacity and pH (p < 0.05). A statistically significant decrease in S. mutans levels was found in both toothpaste groups (p<0.05).

Conclusion: Both toothpaste group showed a statistically significant amount of enamel remineralization. Since theobromine had the added benefits of increasing the salivary pH and decreasing the S.mutans levels, theobromine containing toothpastes can be considered effective agents in remineralizing white spot lesions and can be used in prevention of early enamel lesions.

Keywords: Preschool Child; Preventive Dentistry; Theobromine; Tooth Remineralization; Toothpastes.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: All authors declare that they have no conflicts of interest. This study was not supported by any grant or company.

Figures

Figure 1
Figure 1
LF values before and after using Fluoride toothpaste and Theobromine containing Toothpaste
Figure 2
Figure 2
The frequency of Saliva S. mutans before and after interventions
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Tadić K, Katic V, Spalj S. Caries Experience of the Patients Referred for an Orthodontic Consultation. Acta Stomatol Croat. 2018;52(2):123–31. 10.15644/asc52/2/5 - DOI - PMC - PubMed
    1. Karaca S, Ozbay G. B. K. Primary Zirconia Crown Restorations for Children with Early Childhood Caries. Acta Stomatol Croat. 2013;47:64–71. 10.15644/asc47/1/6 - DOI
    1. Anil S, Anand PS. Early Childhood Caries: Prevalence, Risk Factors, and Prevention. Front Pediatr. 2017. July 18;5:157. 10.3389/fped.2017.00157 - DOI - PMC - PubMed
    1. Walsh T, Worthington HV, Glenny AM, Marinho VC, Jeroncic A. Fluoride toothpastes of different concentrations for preventing dental caries. Cochrane Database Syst Rev. 2019. March 4;3(3):CD007868. 10.1002/14651858.CD007868.pub3 - DOI - PMC - PubMed
    1. Limeback H, Robinson C. Fluoride therapy. Hoboken, NY, USA: John Wiley & Sons; 2012.

LinkOut - more resources