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. 2021 Mar 31:12:653146.
doi: 10.3389/fphar.2021.653146. eCollection 2021.

Guanosine Mechanisms of Action: Toward Molecular Targets

Caio M Massari  1 , Mariachiara Zuccarini  2 , Patrizia Di Iorio  2 , Carla I Tasca  1
Affiliations

Guanosine Mechanisms of Action: Toward Molecular Targets

Caio M Massari et al. Front Pharmacol. .
No abstract available

Keywords: A1R/A2AR heteromers; adenosine receptors; guanosine; neuroprotection; receptors oligomerization.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Guanosine (GUO) interaction with adenosine A1R-A2AR heteromer. Studies with heterologous adenosine receptors transfection showed GUO effects on ligand binding to receptors and intracellular signaling activation require both A1R and A2AR co-expression. Studies evaluating the neuroprotection promoted by GUO showed the protective is effect is abolished by A2AR agonist (CGS21680) and A1R antagonist (DPCPX). This pharmacological modulation also points to an interaction with the A1R-A2AR heteromer.
See this image and copyright information in PMC

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