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. 1988 Jul;38(7):1146-50.
doi: 10.1212/wnl.38.7.1146.

Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance

T R Browne  1 , G K Szabo, J E Evans, B A Evans, D J Greenblatt, M A Mikati
Affiliations

Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance

T R Browne et al. Neurology. 1988 Jul.

Abstract

Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.

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