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Case Reports
. 2021 Apr 1:2021:8880539.
doi: 10.1155/2021/8880539. eCollection 2021.

A Case of Lung Cancer with Brain Metastasis following Late-Onset Bipolar Disorder

Shin-Heng Shen  1   2 , Shwu-Hua Lee  1   2
Affiliations
Case Reports

A Case of Lung Cancer with Brain Metastasis following Late-Onset Bipolar Disorder

Shin-Heng Shen et al. Behav Neurol. .

Abstract

Objective: To describe a case of lung cancer with brain metastasis in a patient who developed new late-onset bipolar disorder 2 years previously.

Background: The typical onset age of bipolar disorder is approximately 20, and the first episode is usually a depressive episode. It is still not clear which age-specific factors contribute to the underlying risk.

Materials and methods: A 65-year-old male patient presented with a new-onset manic episode characterized by labile mood, impulsivity, decreased need for sleep, and grandiosity. He was diagnosed with late-onset bipolar disorder after excluding other possible physiological conditions. He was hospitalized in the acute psychiatric ward, and a combination of mood stabilizers and antipsychotics was prescribed. His mental condition improved, and he remained stable for 2 years. However, he experienced abrupt cognitive decline for 2 months and was referred to the emergency room for physiological examination.

Results: The patient was diagnosed with lung cancer with brain metastasis by brain magnetic resonance imaging and whole-body positron emission tomography.

Conclusion: In geriatric patients, who are at high risk of multiple medical conditions, excluding secondary causes of bipolar disorder is important.

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Conflict of interest statement

The authors have no conflicts of interest relevant to this article.

Figures

Figure 1
Figure 1
Unremarkable chest X-ray at (a) mania onset and (b) 2 years later, with a mass (arrow) in the right upper lobe of the lung.
Figure 2
Figure 2
Brain MRI (a) 10 months after and (b) 2 years after mania onset, with a brain mass at 2 years (arrow).
See this image and copyright information in PMC

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