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Editorial
. 2021 Mar 30;12(7):589-591.
doi: 10.18632/oncotarget.27902.

The long road to TRAIL therapy: a TRAILshort detour

Aswath P Chandrasekar, Mark Maynes, Andrew D Badley
Editorial

The long road to TRAIL therapy: a TRAILshort detour

Aswath P Chandrasekar et al. Oncotarget. .
No abstract available

Keywords: TRAIL; TRAILshort; anti-apoptosis; apoptosis; cancer therapy.

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Conflict of interest statement

CONFLICTS OF INTEREST Authors have no conflicts of interest to declare. ADB is supported by grants from NIAID (grants AI110173 and AI120698) Amfar (#109593) and Mayo Clinic (HH Shieck Khalifa Bib Zayed Al-Nahyan Named Professorship of Infectious Diseases). ADB is a paid consultant for Abbvie and Flambeau Diagnostics, is a paid member of the DSMB for Corvus Pharmaceuticals, Equilium, and Excision Biotherapeutics, has received fees for speaking for Reach MD, owns equity for scientific advisory work in Zentalis and Nference, and is founder and President of Splissen therapeutics.

Figures

Figure 1
Figure 1. The functions of TRAIL and TRAILshort.
(A) TRAIL and TRAILshort may both bind to the TRAIL receptors DR4 and DR5; however TRAILshort does not influence apoptosis. (B) Full length TRAIL has been demonstrated to influence a myriad of cell signaling cascades such as (clockwise from top): Caspase dependent apoptosis, activating the p38/MAPK pathway, suppressing TCR signaling and T-Cell proliferation, induction of NFκB activity, Activation of the PI3K/AKT pathway, and inducing MEKK dependent JNK phosphorylation, however the downstream effects of TRAILshort largely remain a mystery [28].
See this image and copyright information in PMC

References

    1. Altfeld M, Gale M Jr. Nat Immunol. 2015; 16:554–62. 10.1038/ni.3157. - DOI - PubMed
    1. Bień K, et al.. Mediators Inflamm. 2015; 2015:281613. 10.1155/2015/281613. - DOI - PMC - PubMed
    1. Brincks EL, et al.. J Immunol. 2008; 181:4918–25. 10.4049/jimmunol.181.7.4918. - DOI - PMC - PubMed
    1. Cummins N, Badley A. Curr Mol Med. 2009; 9:495–505. 10.2174/156652409788167078. - DOI - PMC - PubMed
    1. Gasper-Smith N, et al.. J Virol. 2008; 82:7700–10. 10.1128/JVI.00605-08. - DOI - PMC - PubMed

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