Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Apr 14;8(4):e00555.
doi: 10.14309/crj.0000000000000555. eCollection 2021 Apr.

Thyroid Disease-Induced Hepatic Dysfunction: A Clinical Puzzle

Chimaobi M Anugwom  1 , Thomas M Leventhal  1
Affiliations
Case Reports

Thyroid Disease-Induced Hepatic Dysfunction: A Clinical Puzzle

Chimaobi M Anugwom et al. ACG Case Rep J. .

Abstract

The diagnostic evaluation of an individual with clinical and laboratory evidence of thyroid dysfunction in the setting of acute liver injury is crucial. There is a complex relationship between the thyroid and the liver, and so, it requires a careful elucidation of the inciting disease process before instituting a treatment plan. We discuss a patient who had presented with coagulopathy, encephalopathy, and laboratory evidence of acute liver injury, hence adjudged to have developed drug-induced acute liver failure and transferred for liver transplant evaluation. She was found to have liver dysfunction from uncontrolled thyroid disease, with immediate and rapid improvement after controlling severe hyperthyroidism.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Trend of liver enzymes during hospitalization.
Figure 2.
Figure 2.
Trend of total bilirubin and international normalized ratio during hospitalization. INR, international normalized ratio.
Figure 3.
Figure 3.
Trend of serum-free thyroxine during hospitalization.
See this image and copyright information in PMC

References

    1. Mendel CM, Cavalieri RR, Weisiger RA. Uptake of thyroxine by the perfused rat liver: Implications for the free hormone hypothesis. Am J Physiol 1988;255(2 Pt 1):E110–9. - PubMed
    1. Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM 2002;95(9):559–69. - PubMed
    1. Zeniya M. Thyroid disease in autoimmune liver diseases [in Japanese]. Nihon Rinsho 1999;57(8):1882–7. - PubMed
    1. Floreani A, Mangini C, Reig A, et al. . Thyroid dysfunction in primary biliary cholangitis: A comparative study at two European centers. Am J Gastroenterol 2017;112(1):114–9. - PubMed
    1. Ferri S, Muratori L, Lenzi M, Granito A, Bianchi FB, Vergani D. HCV and autoimmunity. Curr Pharm Des 2008;14(17):1678–85. - PubMed

Publication types