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. 2021 Mar 30:26:100990.
doi: 10.1016/j.bbrep.2021.100990. eCollection 2021 Jul.

Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index

Tanoy Mazumder  1 , Imran Parvez Mamun  1 , Md Safayat Zaman  1 , A K M Khairul Islam  1 , Shahjala Chowdhury  1 , Md Sharif Reza  1 , Md Saddam Hussain  1
Affiliations

Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index

Tanoy Mazumder et al. Biochem Biophys Rep. .

Abstract

Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of Azadirachta indica A. Juss., Trigonella foenum-graecum L., Allium sativum L. and Zingiber officinale Roscoe in high fat-induced mice with their total phenolic and flavonoid profile. Total phenolic and flavonoid content were determined by Folin-Ciocalteu's and Aluminium chloride UV method respectively. In our study, 55 healthy mice were separated into 11 groups to take their respective treatments. Lipid and uric acid profile were estimated by using the enzymatic colourimetric method. Ethanolic extract of A. indica contained the highest phenolic and flavonoid content. A. indica normal and high fat diet group showed reduced weight gaining tendency than other extract groups. A. indica at a dose of 400 mg/kg body weight significantly (p < 0.001) reduced serum cholesterol (SC), triglyceride (TG), and uric acid (UA) level than other three extracts when compared with the control group. Thus, a considerable correlation was found between serum uric acid reducing potentials of the present experimental extracts with a lipid-lowering profile. Pathological examination revealed that the average weight of liver and kidney were significantly decreased in A. indica normal. Results obtained from the present study it can be concluded that ethanolic extract of A. indica possesses better lipid-lowering efficacy than the other three herbs.

Keywords: Cardiovascular drugs; Cholesterol; Lipid-lowering; Phenolic and flavonoid content; Triglyceride; Uric acid.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Image 1
Graphical abstract
Figure-1
Figure-1
Bodyweight variation of mice of different experimental groups. All values are represented as mean ± SEM where, level of significance stated as ***p < 0.001, **p < 0.01, *p < 0.05 when compared with the control group. All values are represented as mean ± SEM where, level of significance stated as ***p < 0.001, **p < 0.01, *p < 0.05 when compared with the control group.
Figure-2
Figure-2
Comparative fat deposition profile of treatment groups. All values are represented as mean ± SEM where, level of significance stated as ***p < 0.001, **p < 0.01, *p < 0.05 when compared with the control group.
See this image and copyright information in PMC

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