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Case Reports
. 2021 Mar 31;17(2):200-205.
doi: 10.4274/ejbh.galenos.2020.5703. eCollection 2021 Apr.

Three Cases of Breast Metastases from Lung Cancer and Systematic Review of the Literature

Nilgün Güldoğan  1 , Gül Esen İçten  2 , Fatma Tokat  2 , Burçin Tutar  2 , Halil Kara  2 , Taner Korkmaz  2 , Başak Oyan Uluç  2 , Gökhan Demir  2
Affiliations
Case Reports

Three Cases of Breast Metastases from Lung Cancer and Systematic Review of the Literature

Nilgün Güldoğan et al. Eur J Breast Health. .

Abstract

Despite the high prevalence of lung cancer among other primary tumors, metastasis of this particular malignancy in the breast is very rare. We report three new cases of lung cancer with breast metastases and discuss radiological and clinical findings. Radiologically, each case displayed different characteristics. First, one of them had bilateral superficially and deeply located irregular lesions. Second, the patient presented with findings similar to inflammatory breast cancer. The third case had a circumscribed mass, resembling a benign complicated cyst. To guide clinicians for proper patient management, radiologists should be aware of the scope of typical and atypical imaging findings of metastatic involvement of the breast.

Keywords: Breast neoplasm; breast metastasis; breast ultrasound; lung cancer.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
US examination: (a) superficially located irregular solid nodular lesion with echogenic halo at 9 o’clock position in the right breast (arrow). (b) Hyperechoic lesion (in calipers) and a deeply located heterogeneous nodule with an echogenic halo (arrow) at 12 o’clock position in the right breast US: Ultrasonography
Figure 2
Figure 2
(a,b) Mammography (craniocaudal views) shows multiple nodules smaller than 1 cm with indistinct/microlobulated margins (arrows)
Figure 3
Figure 3
Breast biopsy. Small-cell carcinoma (H&E) H&E: Hematoxylin-eosin
Figure 4
Figure 4
Breast MRI examination. (a-b) Fat-saturated T2-weighted images show bilateral multiple irregular hyperintense nodular lesions (arrows). (c-d) Contrast-enhanced T1-weighted subtraction images: most of the lesions displayed rim enhancement (arrows). (e) Diffusion-weighted images ADC map: lesions showed restricted diffusion (arrows) MRI: Magnetic resonance imaging; ADC: Apparent diffusion coefficient
Figure 5
Figure 5
(a) Mammography (left mediolateral oblique view) demonstrates trabecular thickening and skin thickening (arrows) in the lower outer quadrant of the left breast. Retraction of both nipples is noted as incidental finding. (b) Ultrasound of the left breast: irregular, vertically oriented, non-mass lesions (arrows) are seen
Figure 6
Figure 6
(a) Breast biopsy. Adenocarcinoma (H&E). (b) Tumor cells positive with TTF-1 immunostain H&E: Hematoxylin-eosin
Figure 7
Figure 7
(a) Ultrasound of the left breast: superficially located well-defined cyst-like avascular round lesion. (b) Second US examination revealed the solid nature of the nodule and an echogenic halo US: Ultrasonography
Figure 8
Figure 8
Breast biopsy. Small-cell carcinoma with necrosis (H&E) H&E: Hematoxylin-eosin
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