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. 2021 Jul;19(4):281-283.
doi: 10.2450/2021.0117-21. Epub 2021 Apr 15.

Management of cerebral and splanchnic vein thrombosis associated with thrombocytopenia in subjects previously vaccinated with Vaxzevria (AstraZeneca): a position statement from the Italian Society for the Study of Haemostasis and Thrombosis (SISET)

Affiliations

Management of cerebral and splanchnic vein thrombosis associated with thrombocytopenia in subjects previously vaccinated with Vaxzevria (AstraZeneca): a position statement from the Italian Society for the Study of Haemostasis and Thrombosis (SISET)

Paolo Gresele et al. Blood Transfus. 2021 Jul.
No abstract available

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Figures

Figure 1
Figure 1. Proposed flow-chart for the management of cerebral sinus or splanchnic vein thrombosis occurring after Vaxzevria vaccine within a timeframe suggesting a causal relationship
aPTT: activated partial thromboplastin time; CSVT: cerebral sinus venous thrombosis; Dex: dexamethasone; FFP: fresh frozen plasma; GFR: glomerular filtration rate; HIPA: heparin-induced platelet aggregation; ICH: intracranial haemorrhage; Ig-HD: high doses of immunoglobulins; INR: international normalised ratio; i.v.: intravenous; LMWH: low-molecular-weight heparin; SVT: splanchnic vein thrombosis; UFH: unfractionated heparin.

References

    1. Voysey M, Costa Clemens SA, Madhi SA, et al. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021;397:881–91. - PMC - PubMed
    1. The BMJ [internet] Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots. [Accessed on 09/04/2021.];BMJ. 2021 372:n699. doi: 10.1136/bmj.n699. - DOI - PubMed
    1. The BMJ [internet] Covid-19: EMA defends AstraZeneca vaccine as Germany and Canada halt rollouts. BMJ. 2021. [Accessed on 09/04/2021.]. Available at: https://www.bmj.com/content/373/bmj.n883/rapid-responses. - PubMed
    1. European Medicines Agency (EMA) [internet] COVID-19 Vaccine AstraZeneca: benefits still outweigh the risks despite possible link to rare blood clots with low blood platelets. [Accessed on 09/04/2021.]. Available at: https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazeneca-benefits-....
    1. Østergaard SD, Schmidt M, Horváth-Puhó E, et al. Thromboembolism and the Oxford-AstraZeneca COVID-19 vaccine: side-effect or coincidence? Lancet. 2021;397:1441–3. - PMC - PubMed