Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul;46(7):1603-1617.
doi: 10.1007/s11064-021-03325-x. Epub 2021 Apr 19.

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease

Md Sahab Uddin  1   2 , Dewan Md Sumsuzzman  3 , Philippe Jeandet  4 , Tapan Behl  5 , Abdur Rauf  6 , Md Shah Amran  7 , Ghulam Md Ashraf  8   9
Affiliations
Review

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease

Md Sahab Uddin et al. Neurochem Res. 2021 Jul.

Abstract

Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.

Keywords: Alzheimer’s disease; Amyloid beta; Circadian disruption; Neurofibrillary tangles; Rapid eye movement; Sleep deprivation; Slow-wave sleep.

PubMed Disclaimer

References

    1. Sharma P, Sharma A, Fayaz F et al (2020) Biological signatures of Alzheimer’s disease. Curr Top Med Chem 20:770–781. https://doi.org/10.2174/1568026620666200228095553 - DOI - PubMed
    1. Uddin MS, Kabir MT, Rahman MS et al (2020) Revisiting the amyloid cascade hypothesis: from anti-Aβ therapeutics to auspicious new ways for Alzheimer’s disease. Int J Mol Sci 21:5858. https://doi.org/10.3390/ijms21165858 - DOI - PMC
    1. Qiu C, Kivipelto M, von Strauss E (2009) Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11:111–128 - DOI
    1. Prince MJ (2015) World Alzheimer Report 2015, The global impact of dementia: an analysis of prevalence, incidence, cost and trends, 87
    1. Ashraf GM, Ebada MA, Suhail M et al (2021) Dissecting Sex-related cognition between Alzheimer’s disease and diabetes: from molecular mechanisms to potential therapeutic strategies. Oxidative Med Cell Longev 2021:4572471. https://doi.org/10.1155/2021/4572471 - DOI

MeSH terms

LinkOut - more resources