Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

doi:10.1007/s12264-021-00667-y

Review

. 2021 May;37(5):735-745.

doi: 10.1007/s12264-021-00667-y. Epub 2021 Apr 19.

Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

Ti-Fei Yuan^#^{1

2

3}, Yi Dong^#⁴, Li Zhang^#^{5

6}, Jieyu Qi⁷, Chun Yao^{3

8}, Yongjun Wang^{9

10}, Renjie Chai^{11

12}, Yan Liu^{13

14}, Kwok-Fai So^{15

16

17}

Affiliations

¹ Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
² State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Jiulong, Hong Kong SAR, China.
³ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
⁴ Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, 200241, China.
⁵ Joint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
⁶ Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, 510632, China.
⁷ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
⁸ Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
⁹ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. wyjbs@ntu.edu.cn.
¹⁰ Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. wyjbs@ntu.edu.cn.
¹¹ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn.
¹² Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.
¹³ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. yanliu@njmu.edu.cn.
¹⁴ Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. yanliu@njmu.edu.cn.
¹⁵ State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Jiulong, Hong Kong SAR, China. hrmaskf@hku.hk.
¹⁶ Joint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China. hrmaskf@hku.hk.
¹⁷ Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, 510632, China. hrmaskf@hku.hk.

^# Contributed equally.

PMID: 33871821
PMCID: PMC8099989
DOI: 10.1007/s12264-021-00667-y

Review

Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

Ti-Fei Yuan et al. Neurosci Bull. 2021 May.

. 2021 May;37(5):735-745.

doi: 10.1007/s12264-021-00667-y. Epub 2021 Apr 19.

Authors

Ti-Fei Yuan^#^{1

2

3}, Yi Dong^#⁴, Li Zhang^#^{5

6}, Jieyu Qi⁷, Chun Yao^{3

8}, Yongjun Wang^{9

10}, Renjie Chai^{11

12}, Yan Liu^{13

14}, Kwok-Fai So^{15

16

17}

Affiliations

¹ Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
² State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Jiulong, Hong Kong SAR, China.
³ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
⁴ Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, 200241, China.
⁵ Joint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
⁶ Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, 510632, China.
⁷ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
⁸ Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
⁹ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. wyjbs@ntu.edu.cn.
¹⁰ Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. wyjbs@ntu.edu.cn.
¹¹ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn.
¹² Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.
¹³ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. yanliu@njmu.edu.cn.
¹⁴ Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. yanliu@njmu.edu.cn.
¹⁵ State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Jiulong, Hong Kong SAR, China. hrmaskf@hku.hk.
¹⁶ Joint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China. hrmaskf@hku.hk.
¹⁷ Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, 510632, China. hrmaskf@hku.hk.

^# Contributed equally.

PMID: 33871821
PMCID: PMC8099989
DOI: 10.1007/s12264-021-00667-y

Abstract

Stem cell transplantation holds a promising future for central nervous system repair. Current challenges, however, include spatially and temporally defined cell differentiation and maturation, plus the integration of transplanted neural cells into host circuits. Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site, orchestrate the differentiation process, and promote the integration of neural circuitry for functional rehabilitation. All these advantages of neuromodulation make it one potentially valuable tool for further improving the efficiency of stem cell transplantation.

Keywords: Deep brain stimulation; Neuromodulation; Rehabilitation; Stem cell; Transcranial direct current stimulation; Transcranial magnetic stimulation.

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Figures

**Fig. 1**
Neuromodulation techniques used to alter stem cell functions *in vitro* and *in vivo*.

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References

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1. Rossi F, Cattaneo E. Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci. 2002;3:401–409. doi: 10.1038/nrn809. - DOI - PubMed
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[1] Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015;17:11–22. doi: 10.1016/j.stem.2015.06.007. - DOI - PubMed

[2] Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015;17:11–22. doi: 10.1016/j.stem.2015.06.007. - DOI - PubMed

[3] Rossi F, Cattaneo E. Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci. 2002;3:401–409. doi: 10.1038/nrn809. - DOI - PubMed

[4] Rossi F, Cattaneo E. Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci. 2002;3:401–409. doi: 10.1038/nrn809. - DOI - PubMed

[5] Huo W, Liu X, Tan C, Han Y, Kang C, Quan W, et al. Stem cell transplantation for treating stroke: status, trends and development. Neural Regen Res. 2014;9:1643–1648. doi: 10.4103/1673-5374.141793. - DOI - PMC - PubMed

[6] Huo W, Liu X, Tan C, Han Y, Kang C, Quan W, et al. Stem cell transplantation for treating stroke: status, trends and development. Neural Regen Res. 2014;9:1643–1648. doi: 10.4103/1673-5374.141793. - DOI - PMC - PubMed

[7] Miocinovic S, Somayajula S, Chitnis S, Vitek JL. History, applications, and mechanisms of deep brain stimulation. JAMA Neurol. 2013;70:163–171. doi: 10.1001/2013.jamaneurol.45. - DOI - PubMed

[8] Miocinovic S, Somayajula S, Chitnis S, Vitek JL. History, applications, and mechanisms of deep brain stimulation. JAMA Neurol. 2013;70:163–171. doi: 10.1001/2013.jamaneurol.45. - DOI - PubMed

[9] Johnson MD, Miocinovic S, McIntyre CC, Vitek JL. Mechanisms and targets of deep brain stimulation in movement disorders. Neurotherapeutics. 2008;5:294–308. doi: 10.1016/j.nurt.2008.01.010. - DOI - PMC - PubMed

[10] Johnson MD, Miocinovic S, McIntyre CC, Vitek JL. Mechanisms and targets of deep brain stimulation in movement disorders. Neurotherapeutics. 2008;5:294–308. doi: 10.1016/j.nurt.2008.01.010. - DOI - PMC - PubMed

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Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

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Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

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