Neonatal mast cells and transplacental IgE transfer: A mechanism of disease inheritance or of passive infant barrier defense?

Affiliations

¹ Department of Medicine, Harvard Medical School, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, Mass.
² Department of Medicine, Harvard Medical School, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, Mass. Electronic address: jboyce@rics.bwh.harvard.edu.

Editorial

Daniel F Dwyer et al. J Allergy Clin Immunol. 2021 Jul.

. 2021 Jul;148(1):76-77.

doi: 10.1016/j.jaci.2021.02.046. Epub 2021 Apr 16.

¹ Department of Medicine, Harvard Medical School, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, Mass.
² Department of Medicine, Harvard Medical School, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, Mass. Electronic address: jboyce@rics.bwh.harvard.edu.

No abstract available

Keywords: IgE; Mast cells; atopy; sensitization.

Comment in

Maternal IgE is transferred to fetuses with IgG and minimally sensitizes fetal/neonatal skin mast cells.
Honda Keith Y, Kabashima K. Honda Keith Y, et al. J Allergy Clin Immunol. 2021 Sep;148(3):903-904. doi: 10.1016/j.jaci.2021.05.040. Epub 2021 Jun 26. J Allergy Clin Immunol. 2021. PMID: 34183165 No abstract available.
Reply.
Dwyer DF, Boyce JA. Dwyer DF, et al. J Allergy Clin Immunol. 2021 Sep;148(3):904. doi: 10.1016/j.jaci.2021.05.041. Epub 2021 Jun 26. J Allergy Clin Immunol. 2021. PMID: 34183166 No abstract available.

Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE.
Msallam R, Balla J, Rathore APS, Kared H, Malleret B, Saron WAA, Liu Z, Hang JW, Dutertre CA, Larbi A, Chan JKY, St John AL, Ginhoux F. Msallam R, et al. Science. 2020 Nov 20;370(6519):941-950. doi: 10.1126/science.aba0864. Epub 2020 Oct 29. Science. 2020. PMID: 33122426