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. 1988 Jul;85(13):4770-4.
doi: 10.1073/pnas.85.13.4770.

Sources and evolution of human Alu repeated sequences

R J Britten  1 , W F Baron, D B Stout, E H Davidson
Affiliations

Sources and evolution of human Alu repeated sequences

R J Britten et al. Proc Natl Acad Sci U S A. 1988 Jul.

Abstract

Alu repeated sequences arising in DNA of the human lineage during about the last 30 million years are closely similar to a modern consensus. Alu repeats arising at earlier times share correlated blocks of differences from the current consensus at diagnostic positions in the sequence. Using these 26 positions, we can recognize four subfamilies and the older ones are each successively closer to the 7SL sequence. It appears that there has existed a series of conserved genes that are the primary sources of the Alu repeat family, presumably through retroposition. These genes have probably replaced each other in overlapping relays during the evolution of primates.

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References

    1. Nature. 1982 Oct 21;299(5885):691-8 - PubMed
    1. J Mol Biol. 1979 Feb 5;127(4):437-60 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Aug;80(16):5012-6 - PubMed
    1. Nucleic Acids Res. 1983 Nov 11;11(21):7595-610 - PubMed
    1. J Mol Evol. 1984;20(1):2-15 - PubMed

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