Clinical Translation of Anti-aging Associated Genetics: Current Progress and Challenges

Abstract

Background: Currently, the focus of anti-aging research has been changed from geriatrics to biogerontology. This has taken anti-aging strategies from cost-effective but palliative therapeutics to active, molecular approaches.

Outline: Over the years, a large body of basic gerontological research has indicated that the process of biological aging is closely associated with genetic factors. This leads to the development of various gene therapies such as RNA interference technology and results in a subsequent need for translating laboratory achievements into clinical applications. The translation has been a tremendous challenge at this stage with respect to the practicality, safety, and effectiveness of the genetic manipulation techniques.

Objective: This review summarizes the current development of anti-aging strategies and the progress in the translation of laboratory achievements into clinical applications, highlights challenges encountered, and provides a prospective outlook for future anti-aging research.

Keywords: Lifespan; RNAi; anti-aging; clinical trials; genetic manipulation.; genome-wide association studies.