Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 19;47(1):95.
doi: 10.1186/s13052-021-01041-4.

Kawasaki disease recurrence in the COVID-19 era: a systematic review of the literature

Alice Annalisa Medaglia  1   2 , Lucia Siracusa  3 , Claudia Gioè  4   3 , Salvatore Giordano  3 , Antonio Cascio  4 , Claudia Colomba  4
Affiliations

Kawasaki disease recurrence in the COVID-19 era: a systematic review of the literature

Alice Annalisa Medaglia et al. Ital J Pediatr. .

Abstract

Kawasaki disease (KD) is a vasculitis of unknown origin of small and medium caliber blood vessels, especially involving coronary arteries and is the leading cause of acquired heart disease in childhood in developed countries. Although rarely, it can recur: most recurrences occur within 2 years of the initial episode. No data are available on incidence of recurrent KD in Europe and multiple recurrences are rarely seen. We reviewed the medical literature on Kawasaki disease recurrence and reported a new case of Kawasaki disease recurrence in a child with SARS-CoV-2 infection. We believe that in our case SARS Cov2 acted as a trigger capable to determine, in a genetically susceptible individual, a second recurrence of the disease. In the Covid-19 era we affirm the importance for Kawasaki disease to be tested for SARS Cov2 infection.

Keywords: Covid-19; Kawasaki disease recurrence; Recurrent Kawasaki disease; Sars-Cov2.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Search strategy for the systematic review
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. 2017;135(17):e927–e999. doi: 10.1161/CIR.0000000000000484. - DOI - PubMed
    1. Goswami N, Marzan K, De Oliveira E, Wagner-Lees S, Szmuszkovicz J. Recurrent Kawasaki disease: a case report of three separate episodes at >4-year intervals. Children. 2018;5(11):155. doi: 10.3390/children5110155. - DOI - PMC - PubMed
    1. Guleria S, Pilania RK, Jindal AK, Bhattarai D, Suri D, Singh S. Recurrent Kawasaki disease at a tertiary care center in Chandigarh, north West India: 24 years of clinical experience. Int J Rheum Dis. 2019;22(7):1183–1187. doi: 10.1111/1756-185X.13519. - DOI - PubMed
    1. Kaur G, Gupta J, Verma L, Passi S, Joshi M. Recurrent Kawasaki Disease Presenting to Dentists: “Think Beyond Dentition”. Int J Clin Pediatr Dent 2018;11(6):535–535. doi:10.5005/jp-journals-10005-1571, Recurrent Kawasaki Disease Presenting to Dentists: “Think Beyond Dentition”. - PMC - PubMed
    1. Ulloa-Gutierrez R, Alphonse MP, Dhanranjani A, Yeung RSM. Kawasaki disease-associated cytokine storm syndrome. In: Cytokine Storm Syndrome. Springer Int Publish; 2019:393–406. doi:10.1007/978-3-030-22094-5_23, Kawasaki Disease-Associated Cytokine Storm Syndrome.

Publication types