Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Apr 19;14(4):e240980.
doi: 10.1136/bcr-2020-240980.

Familial bilateral nodular oncocytic hyperplasia of the parotid gland in mother and son

Yinan Zhu  1 , Manuela Cresswell  2 , Jonathan Miles Charnock  3 , Philip Reece  4
Affiliations
Case Reports

Familial bilateral nodular oncocytic hyperplasia of the parotid gland in mother and son

Yinan Zhu et al. BMJ Case Rep. .

Abstract

This case series reports familial cases of nodular oncocytic hyperplasia (NOH) diagnosed in a mother and her son, 15 years apart. A 39-year-old man presented in 2003 with a lump below his left ear. Magnetic resonance imaging (MRI) performed showed multifocal parotid nodules and a diagnosis of NOH was histopathologically confirmed following left total parotidectomy. Two years later, he represented with similar symptoms on the right side. NOH was diagnosed following excision of his right parotid gland. In 2018, his 73-year-old mother presented with left ear pain and a lump below her left ear. An MRI scan showed multiple lesions within both parotid glands and bilateral NOH was once again diagnosed following a left superficial parotidectomy and right total parotidectomy. We believe that this is the first reported case of bilateral familial NOH.

Keywords: ear; nose and throat/otolaryngology; otolaryngology / ENT.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Case I: Histology of right parotid gland lesion at 20× (left) and at 100× (right) magnification, stained using H&E. The black stars (left slide) mark unencapsulated oncocytic nodules on a background of normal parotid gland tissue. A higher power view (right slide) shows oncocytes with ample granular cytoplasm and centrally located nuclei.
Figure 2
Figure 2
Case I: Histology of left parotid gland recurrent NOH lesion at 20× (top left), 40× (top right) 100× (bottom left) and 200× (bottom right) magnification, stained using H&E. The black cross shows an area of central necrosis, reactive inflammation and squamous metaplasia within the oncocytic nodule. The black arrows show areas of squamous metaplasia (dark purple staining). The bottom left slide shows a high power view of the central necrotic tissue and the bottom right slide shows a high power view of squamous metaplasia at the edge of the necrotic tissue with some inflammation.
Figure 3
Figure 3
Case II: T2-weighted parotid MRI scan in the axial section. The white arrows point to the bilateral parotid nodules.
Figure 4
Figure 4
Case II: Histology of right parotid gland lesion at 20× (left) and at 100× (right) magnification, stained using H&E. The black stars (left slide) mark unencapsulated oncocytic nodules. The edges of one of these nodules is magnified (right slide).
See this image and copyright information in PMC

References

    1. Kinoshita Y, Harada H, Kobayashi TK, et al. . Multifocal adenomatous oncocytic hyperplasia of the parotid gland. Case Rep Oncol 2014;7:819–24. 10.1159/000370146 - DOI - PMC - PubMed
    1. Bannister M, Thompson CSG, Conn B. Bilateral submandibular gland nodular oncocytic hyperplasia with papillary cystadenoma-like areas. BMJ Case Rep 2018;2018:1–3. 10.1136/bcr-2018-226145 - DOI - PMC - PubMed
    1. Kurelac I, Salfi NC, Ceccarelli C, et al. . Human papillomavirus infection and pathogenic mitochondrial DNA mutation in bilateral multinodular oncocytic hyperplasia of the parotid. Pathology 2014;46:250–3. 10.1097/PAT.0000000000000079 - DOI - PubMed
    1. EI-Naggar AK, Chan JKC, Grandis JR. WHO classification of tumours. 4th ed. Lyon: International Agency for Research on Cancer (IARC), 2017.
    1. Strassburger S, Hyckel P, Kosmehl H. Multifocal oncocytic adenomatous hyperplasia of the parotid gland. A case report. Int J Oral Maxillofac Surg 1999;28:457–8. 10.1016/S0901-5027(99)80061-7 - DOI - PubMed

Publication types