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. 2021 Jun;41(6):1441-1447.
doi: 10.1038/s41372-021-01054-1. Epub 2021 Apr 19.

Relationship of patent ductus arteriosus management with neonatal AKI

Ronnie Guillet  1 , David T Selewski  2 , Russell Griffin  3 , Shantanu Rastogi  4 , David J Askenazi  3 , Carl T D'Angio  5 ; Neonatal Kidney Collaborative
Collaborators, Affiliations

Relationship of patent ductus arteriosus management with neonatal AKI

Ronnie Guillet et al. J Perinatol. 2021 Jun.

Abstract

Objective: Investigate relationship between management of patent ductus arteriosus (PDA) and acute kidney injury (AKI) in very low birthweight neonates.

Study design: Retrospective cohort study of neonates, <1500 g, admitted to 24 NICUs, 1/1/14 - 3/31/14. AKI diagnosed using the neonatal modified KDIGO definition; diagnosis and treatment of PDA extracted from the medical record. Demographics, clinical characteristics, and AKI stage compared using chi-square and analysis of variance. A general estimating equation logistic regression used to estimate adjusted odds ratios.

Results: Of 526 neonates with sufficient data to diagnose AKI, 157 (30%) had PDA (61 conservative management, 62 pharmacologic treatment only, 34 surgical ligation). In analyses adjusted for sex, birthweight, gestational age, caffeine, nephrotoxin exposure, vasopressor and mechanical ventilation use, with conservative management as reference, there were no differences among treatment cohorts in the odds of AKI.

Conclusion: The underlying physiology of PDA, not management strategy, may determine the likelihood of AKI in neonates <1500 g.

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Conflict of interest statement

Financial Disclosure Statement:

All authors declare no real or perceived conflicts of interest that could affect the study design, collection, analysis and interpretation of data, writing of the report, or the decision to submit for publication.

Figures

Figure 1:
Figure 1:
Study population CONSORT diagram
See this image and copyright information in PMC

Comment in

References

    1. Elmas AT, Tabel Y, Ozdemir R. Risk factors and mortality rate in premature babies with acute kidney injury. J Clin Lab Anal 2018; 32 (7):e22441. - PMC - PubMed
    1. Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, et al. Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a retrospective cohort study. Front Pediatr 2016; 4:68. - PMC - PubMed
    1. Srinivasan N, Schwartz A, John E, Price R, Amin S. Acute kidney injury impairs postnatal renal adaptation and increases morbidity and mortality in very low-birth-weight infants. Am J Perinatol. 2018; 35(1):39–47. - PubMed
    1. Weintraub AS, Connors J, Carey A, Blanco V, Green RS. The spectrum of onset of acute kidney injury in preterm infants less than 30 weeks gestation. J Perinatol 2016; 36:47–480. - PubMed
    1. Velazquez DM, Reidy KJ, Sharma M, Kim M, Vega M, Havranek T. The effect of hemodynamically significant patent ductus arteriosus on acute kidney injury and systemic hypertension in extremely low gestational age newborns. J Matern Fetal Neonatal Med. 2019; 32(19):3209–3214. - PubMed

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