Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May;22(5):539-540.
doi: 10.1038/s41590-021-00923-3.

Immunity after SARS-CoV-2 infections

Prasanna Jagannathan  1   2 , Taia T Wang  3   4   5
Affiliations
Comment

Immunity after SARS-CoV-2 infections

Prasanna Jagannathan et al. Nat Immunol. 2021 May.

Abstract

T cell responses probably play important roles in the control of SARS-CoV-2 infection, but they have been relatively understudied. Data now suggest that the majority of infected individuals develop robust and long-lasting T cell immunity, which has implications for the durability of immunity and future vaccine approaches.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Correlations between SARS-CoV-2-specific T cell responses, disease severity and peak antibody response.
Zuo et al. measured SARS-CoV-2-specific T cell responses in 100 individuals six months after infection. SARS-CoV-2-specific T cell responses were measured by IFN-γ ELISpot and intracellular cytokine staining and correlated with both initial symptoms and the peak antibody response.
See this image and copyright information in PMC

Comment on

  • Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
    Zuo J, Dowell AC, Pearce H, Verma K, Long HM, Begum J, Aiano F, Amin-Chowdhury Z, Hoschler K, Brooks T, Taylor S, Hewson J, Hallis B, Stapley L, Borrow R, Linley E, Ahmad S, Parker B, Horsley A, Amirthalingam G, Brown K, Ramsay ME, Ladhani S, Moss P. Zuo J, et al. Nat Immunol. 2021 May;22(5):620-626. doi: 10.1038/s41590-021-00902-8. Epub 2021 Mar 5. Nat Immunol. 2021. PMID: 33674800 Free PMC article.

References

    1. Grifoni A et al. Cell 181, 1489–1501.e15 (2020). - PMC - PubMed
    1. Sekine T et al. Cell 183, 158–168.e14 (2020). - PubMed
    1. Rydyznski Moderbacher C et al. Cell 183, 996–1012.e19 (2020). - PMC - PubMed
    1. Braun J et al. Nature 587, 270–274 (2020). - PubMed
    1. Dan JM et al. Science 371, eabf4063 (2021). - PubMed

Publication types

Substances