The cold truth: the role of cryotherapy in the treatment of injury and recovery from exercise
- PMID: 33877402
- DOI: 10.1007/s00421-021-04683-8
The cold truth: the role of cryotherapy in the treatment of injury and recovery from exercise
Abstract
Cryotherapy is utilized as a physical intervention in the treatment of injury and exercise recovery. Traditionally, ice is used in the treatment of musculoskeletal injury while cold water immersion or whole-body cryotherapy is used for recovery from exercise. In humans, the primary benefit of traditional cryotherapy is reduced pain following injury or soreness following exercise. Cryotherapy-induced reductions in metabolism, inflammation, and tissue damage have been demonstrated in animal models of muscle injury; however, comparable evidence in humans is lacking. This absence is likely due to the inadequate duration of application of traditional cryotherapy modalities. Traditional cryotherapy application must be repeated to overcome this limitation. Recently, the novel application of cooling with 15 °C phase change material (PCM), has been administered for 3-6 h with success following exercise. Although evidence suggests that chronic use of cryotherapy during resistance training blunts the anabolic training effect, recovery using PCM does not compromise acute adaptation. Therefore, following exercise, cryotherapy is indicated when rapid recovery is required between exercise bouts, as opposed to after routine training. Ultimately, the effectiveness of cryotherapy as a recovery modality is dependent upon its ability to maintain a reduction in muscle temperature and on the timing of treatment with respect to when the injury occurred, or the exercise ceased. Therefore, to limit the proliferation of secondary tissue damage that occurs in the hours after an injury or a strenuous exercise bout, it is imperative that cryotherapy be applied in abundance within the first few hours of structural damage.
Keywords: Cooling; Cryostimulation; Inflammation; Metabolism; Muscle damage.
Similar articles
-
Don't Lose Your Cool With Cryotherapy: The Application of Phase Change Material for Prolonged Cooling in Athletic Recovery and Beyond.Front Sports Act Living. 2020 Oct 15;2:118. doi: 10.3389/fspor.2020.00118. eCollection 2020. Front Sports Act Living. 2020. PMID: 33345107 Free PMC article. Review.
-
Effects of air-pulsed cryotherapy on neuromuscular recovery subsequent to exercise-induced muscle damage.Am J Sports Med. 2013 Aug;41(8):1942-51. doi: 10.1177/0363546513490648. Epub 2013 Jun 5. Am J Sports Med. 2013. PMID: 23739686 Clinical Trial.
-
Whole body cryotherapy, cold water immersion, or a placebo following resistance exercise: a case of mind over matter?Eur J Appl Physiol. 2019 Jan;119(1):135-147. doi: 10.1007/s00421-018-4008-7. Epub 2018 Oct 11. Eur J Appl Physiol. 2019. PMID: 30310979
-
Prolonged cooling with phase change material enhances recovery and does not affect the subsequent repeated bout effect following exercise.Eur J Appl Physiol. 2020 Feb;120(2):413-423. doi: 10.1007/s00421-019-04285-5. Epub 2019 Dec 11. Eur J Appl Physiol. 2020. PMID: 31828479 Clinical Trial.
-
The Effectiveness of Photobiomodulation Therapy Versus Cryotherapy for Skeletal Muscle Recovery: A Critically Appraised Topic.J Sport Rehabil. 2019 Jul 1;28(5):526-531. doi: 10.1123/jsr.2017-0359. Epub 2019 Jan 29. J Sport Rehabil. 2019. PMID: 29952693 Review.
Cited by
-
The Application of Recovery Strategies in Basketball: A Worldwide Survey.Front Physiol. 2022 Jun 16;13:887507. doi: 10.3389/fphys.2022.887507. eCollection 2022. Front Physiol. 2022. PMID: 35784884 Free PMC article.
-
Clinical Evolution and Safety of a Cryotherapy - Based Spray for Mild to Moderate Joint and Muscle Pain: A Descriptive Observational Study.Int J Sports Phys Ther. 2025 Feb 1;20(2):243-252. doi: 10.26603/001c.128589. eCollection 2025. Int J Sports Phys Ther. 2025. PMID: 39959416 Free PMC article.
-
Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19.Sci Total Environ. 2023 Feb 10;859(Pt 1):160163. doi: 10.1016/j.scitotenv.2022.160163. Epub 2022 Nov 14. Sci Total Environ. 2023. PMID: 36395835 Free PMC article.
-
Whole-body cryotherapy can reduce the inflammatory response in humans: a meta-analysis based on 11 randomized controlled trials.Sci Rep. 2025 Mar 5;15(1):7759. doi: 10.1038/s41598-025-90396-3. Sci Rep. 2025. PMID: 40044835 Free PMC article.
-
Clinical Applications and Potential Mechanism of Cold Acclimation Therapy.J Multidiscip Healthc. 2025 Jul 19;18:4113-4120. doi: 10.2147/JMDH.S525146. eCollection 2025. J Multidiscip Healthc. 2025. PMID: 40703584 Free PMC article. Review.
References
-
- Abrams G (1997) Response of the body to injury: inflammation and repair. In: pathophysiology: clinical concepts of disease processes. (5th ed), 38–58
-
- Algafly AA, George KP, Herrington L (2007) The effect of cryotherapy on nerve conduction velocity, pain threshold and pain tolerance * commentary. Br J Sports Med 41(6):365–369. https://doi.org/10.1136/bjsm.2006.031237 - DOI - PubMed - PMC
-
- Amon M, Menger MD, Vollmar B (2003) Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-α-induced microcirculatory dysfunction and apoptotic cell death. FASEB J 17(2):175–185. https://doi.org/10.1096/fj.02-0368com - DOI - PubMed
-
- Armstrong RB (1990) Initial events in exercise-induced muscular injury. Med Sci Sports Exerc 22(4):429–435 - PubMed
-
- Armstrong RB, Warren GL, Warren JA (1991) Mechanisms of exercise-induced muscle fibre injury. Sports Med 12(3):184–207 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical