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. 2021 Aug;26(8):1461-1468.
doi: 10.1007/s10147-021-01925-9. Epub 2021 Apr 20.

Long-term results of fluorescence and indigo carmine blue dye-navigated sentinel lymph node biopsy

Sota Asaga  1 , Ai Tsuchiya  2 , Yoshiharu Ishizaka  2 , Kaisuke Miyamoto  2 , Hiroki Ito  2   3 , Hirotsugu Isaka  2 , Tomohiro Chiba  4   5 , Shigeru Imoto  2 , Hiroshi Kamma  4
Affiliations

Long-term results of fluorescence and indigo carmine blue dye-navigated sentinel lymph node biopsy

Sota Asaga et al. Int J Clin Oncol. 2021 Aug.

Abstract

Background: Sentinel lymph node biopsy is widely applied for the management of clinically node-negative breast cancer, and a radioisotope with a blue dye are most often used as tracers. Fluorescence of indocyanine green could also potentially be used as tracer. This study aimed to demonstrate the long-term survival results of fluorescence-guided sentinel lymph node biopsy.

Patients and methods: Patients with clinically node-negative breast cancer who underwent surgery as initial treatment were included in this study. Both fluorescence of indocyanine green and indigo carmine blue dye were used as tracers. Axillary lymph node dissection was omitted unless metastasis was pathologically proven in sentinel nodes. Breast cancer recurrence and death were recorded and prognostic factors were identified using disease-free survival and overall survival data.

Results: A total of 565 patients were analyzed. There were 14 (2.5%) patients whose sentinel nodes could not be identified, yielding an identification rate of 97.5%. Axillary dissection was performed in 90 patients. Forty-three recurrences including 6 ipsilateral axilla recurrence and 13 deaths were observed during the median 83 months of follow-up period. Seven-year disease-free and overall survival were 92.4% and 97.3%, respectively. Multivariate analyses demonstrated that pre-menopausal status and invasive lobular carcinoma were significant unfavorable prognostic factors of disease-free survival. Half of ipsilateral axilla recurrences occurred within 5 years after surgery and these recurrences were correlated with inappropriate adjuvant therapy.

Conclusion: Fluorescence-guided sentinel lymph node biopsy demonstrated favorable prognostic results and could be alternative to the radioisotope for clinically node-negative breast cancer.

Keywords: Blue dye; Breast cancer; Indocyanine green fluorescence; Node-negative; Radioisotope; Sentinel lymph node biopsy.

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