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Review
. 2021 Apr;41(2):236-249.
doi: 10.1007/s11596-021-2342-1. Epub 2021 Apr 20.

Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

Hua-Hua Jiang  1 , Yao-Yao Du  1 , Yu-Feng Li  2
Affiliations
Review

Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

Hua-Hua Jiang et al. Curr Med Sci. 2021 Apr.

Abstract

Ovary plays an important role in the female reproductive system. The maintenance and regulation of ovarian function are affected by various physical and chemical factors. With the development of industrialization, environmental pollutants have caused great harm to public health. Phthalates, as a class of endocrine-disrupting chemicals (EDCs), are synthesized and used in large quantities as plasticizers due to their chemical properties. They are easily released into environment because of their noncovalent interactions with substances, causing human exposure and possibly impairing ovary. In recent years, more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases. And it is urgent to study the role of methylation, gene imprinting, miRNA, and other epigenetic mechanisms in reproductive toxicology.

Keywords: epigenetics; methylation; miRNAs; ovarian toxicity; phthalates; reproductive health.

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