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Comment
. 2021 Jul;100(1):24-26.
doi: 10.1016/j.kint.2021.04.002. Epub 2021 Apr 17.

SGLT-2 inhibition in IgA nephropathy: the new standard of care?

Jonathan Barratt  1 , Jürgen Floege  2
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Free article
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SGLT-2 inhibition in IgA nephropathy: the new standard of care?

Jonathan Barratt et al. Kidney Int. 2021 Jul.
Free article

Abstract

Despite supportive measures that slow the rate of progression of chronic kidney disease in IgA nephropathy, many patients still progress to end-stage kidney disease. Currently employed immunosuppressive strategies lack conclusive efficacy data, while there is evidence for treatment-emergent toxicity. A subanalysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease Trial, which encompassed 270 patients with a diagnosis of IgA nephropathy, now provides early evidence that dapagliflozin may be a safe and effective addition to current standard of care in IgA nephropathy.

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