Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Apr 20;21(1):181.
doi: 10.1186/s12876-021-01764-y.

Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis

Masoud Keikha  1   2 , Mohsen Karbalaei  3
Affiliations
Meta-Analysis

Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis

Masoud Keikha et al. BMC Gastroenterol. .

Abstract

Background: In general, all virulence factors of Helicobacter pylori (H. pylori) are involved in its infections. However, recent studies have shown that the homB gene is one of the virulence genes that affects the severity of the clinical results of this bacterium.

Methods: The main purpose of this study was to investigate the relationship between the presence of homB gene in H. pylori and the progression of its infection to peptic ulcer and gastric cancer. In the present study, we conducted a systematic search to collect all articles related to the effect of homB-positive strains on clinical outcomes. Finally, 12 eligible studies according to our criteria were included in this meta-analysis and the effect of homB gene on gastric ulcer and gastric cancer diseases was evaluated by summary odds ratio (OR).

Results: Current results showed that the homB-positive strains significantly increase the risk of peptic ulcer (OR 1.36; 1.07-1.72 with 95% CIs), especially in western countries (OR 1.61; 1.20-2.14 with 95% CIs). Moreover, we observed a positive association between the homB gene and risk of gastric cancer (OR 2.16; 1.37-3.40 with 95% CIs). In addition, based on subgroup analysis, it was found that the presence of this gene in H. pylori strains increases the risk of gastric cancer in the Asian population (OR 3.71; 1.85-7.45 with 95% CIs).

Conclusions: Overall, in the present study we found that homB gene is responsible for the progressing of primary infection to severe complications, in particular peptic ulcer in western countries and gastric cancer in Asian countries.

Keywords: Gastric cancer; Helicobacter pylori; HomB gene; MALT; Peptic ulcer.

PubMed Disclaimer

Conflict of interest statement

There is no any conflict of interest among the all authors.

Figures

Fig. 1
Fig. 1
The flowchart of study selection and included studies
Fig. 2
Fig. 2
Random-effects meta-analysis forest plot of the OR of peptic ulceration according to homB-positive H. pylori infection in eleven included studies
Fig. 3
Fig. 3
Random-effects meta-analysis forest plot of the OR of gastric adenocarcinoma according to homB-positive H. pylori infection in five included studies
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Marshall B, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. The lancet. 1984;323(8390):1311–1315. - PubMed
    1. Axon A. Helicobacter pylori and public health. Helicobacter. 2014;19:68–73. - PubMed
    1. Karbalaei M, Khorshidi M, Sisakht-pour B, Ghazvini K, Farsiani H, Youssefi M, et al. What are the effects of IL-1β (rs1143634), IL-17A promoter (rs2275913) and TLR4 (rs4986790) gene polymorphism on the outcomes of infection with H. pylori within as Iranian population: a systematic review and meta-analysis. Gene Rep. 2020:100735.
    1. Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, et al. Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. The Lancet. 2002;359(9310):931–935. - PubMed
    1. Kato S, Nishino Y, Ozawa K, Konno M, Maisawa SI, Toyoda S, et al. The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease. J Gastroenterol. 2004;39(8):734–738. - PubMed