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. 2021 Apr 20;14(1):111.
doi: 10.1186/s12920-021-00956-5.

Susceptibility loci for pancreatic cancer in the Brazilian population

Mateus Nóbrega Aoki  1 , Angelika Stein  2 , Jaqueline Carvalho de Oliveira  3 , Roger Chammas  4 , Miyuki Uno  4 , Francielle Boçon de Araújo Munhoz  5 , Anelis Maria Marin  5 , Federico Canzian  2
Affiliations

Susceptibility loci for pancreatic cancer in the Brazilian population

Mateus Nóbrega Aoki et al. BMC Med Genomics. .

Abstract

Background: Pancreatic adenocarcinoma (PA) is a very aggressive cancer and has one of the poorest prognoses. Usually, the diagnosis is late and resistant to conventional treatment. Environmental and genetic factors contribute to the etiology, such as tobacco and alcohol consumption, chronic pancreatitis, diabetes and obesity. Somatic mutation in pancreatic cancer cells are known and SNP profile by GWAS could access novel genetic risk factors for this disease in different population context. Here we describe a SNP panel for Brazilian pancreatic cancer, together with clinical and epidemiological data.

Methods: 78 pancreatic adenocarcinoma and 256 non-pancreatic cancer subjects had 25 SNPs genotyped by real-time PCR. Unconditional logistic regression methods were used to assess the main effects on PA risk, using allelic, co-dominant and dominant inheritance models.

Results: 9 SNPs were nominally associated with pancreatic adenocarcinoma risk, with 5 of the minor alleles conferring protective effect while 4 related as risk factor. In epidemiological and clinical data, tobacco smoking, diabetes and pancreatitis history were significantly related to pancreatic adenocarcinoma risk. Polygenic risk scores computed using the SNPs in the study showed strong associations with PA risk.

Conclusion: We could assess for the first time some SNPs related with PA in Brazilian populations, a result that could be used for genetic screening in risk population such as familial pancreatic cancer, smokers, alcohol users and diabetes patients.

Keywords: Association study; Brazil; Genetic susceptibility; Pancreatic cancer; SNP.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Clinical data for lymph node dissection and positivity in PA patients
See this image and copyright information in PMC

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References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A, Global cancer statistics GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(2018):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30. doi: 10.3322/caac.21590. - DOI - PubMed
    1. Chand S, O’Hayer K, Blanco FF, Winter JM, Brody JR. The landscape of pancreatic cancer therapeutic resistance mechanisms. Int J Biol Sci. 2016;12:273–282. doi: 10.7150/ijbs.14951. - DOI - PMC - PubMed
    1. Klein AP. Pancreatic cancer: a growing burden. Lancet Gastroenterol Hepatol. 2019;4:895–896. doi: 10.1016/S2468-1253(19)30323-1. - DOI - PMC - PubMed
    1. Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid Liver, and Pancreas Cancers in the United States. Cancer Res. 2014;74:2913–2921. doi: 10.1158/0008-5472.CAN-14-0155. - DOI - PubMed