Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr 20;14(4):e239153.
doi: 10.1136/bcr-2020-239153.

Tale of two viruses: parvovirus B19 and HIV

Hayley Hernstadt  1   2 , Paul Randell  3 , Sarah Fidler  3 , Caroline Foster  4
Affiliations
Review

Tale of two viruses: parvovirus B19 and HIV

Hayley Hernstadt et al. BMJ Case Rep. .

Abstract

We present a HIV-infected patient who developed severe anaemia due to chronic parvovirus B19 infection and subsequently had an unplanned pregnancy. This is in the context of poor adherence to antiretroviral therapy and significant immunosuppression; there was a delay in diagnosis of chronic parvovirus infection due to attribution of anaemia to HIV. She received immunoglobulin therapy and effective antiretroviral therapy, with reduction in parvovirus load and improvement in anaemia. She was counselled regarding the need for monitoring in pregnancy due to risk of intrauterine infection. We review the literature of management of chronic parvovirus infection in the immunosuppressed and the consequences of intrauterine infection.

Keywords: HIV / AIDS; haematology (incl blood transfusion); infectious diseases; materno-fetal medicine.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Viral loads and CD4 counts over time. *One course of IVIG given at 500 mg/kg/day for 4 days. IVIG, intravenous immunoglobulin.
See this image and copyright information in PMC

References

    1. de Jong EP, de Haan TR, Kroes ACM, et al. Parvovirus B19 infection in pregnancy. J Clin Virol 2006;36:1–7. 10.1016/j.jcv.2006.01.004 - DOI - PubMed
    1. Young NS, Brown KE. Parvovirus B19. N Engl J Med 2004;350:586–97. 10.1056/NEJMra030840 - DOI - PubMed
    1. Heegaard ED, Brown KE. Human parvovirus B19. Clin Microbiol Rev 2002;15:485–505. 10.1128/CMR.15.3.485-505.2002 - DOI - PMC - PubMed
    1. Kelly HA, Siebert D, Hammond R, et al. The age-specific prevalence of human parvovirus immunity in Victoria, Australia compared with other parts of the world. Epidemiol Infect 2000;124:449–57. 10.1017/S0950268899003817 - DOI - PMC - PubMed
    1. Koch WC, Adler SP. Human parvovirus B19 infections in women of childbearing age and within families. Pediatr Infect Dis J 1989;8:83–7. - PubMed

MeSH terms