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Comparative Study
. 2021 Apr 23;100(16):e25635.
doi: 10.1097/MD.0000000000025635.

Analysis of metastasis and survival between extrahepatic and intrahepatic cholangiocarcinoma: A large population-based study

Peng Liao  1 , Li Cao  1 , Hang Chen  2 , Shui-Zi Pang  3
Affiliations
Comparative Study

Analysis of metastasis and survival between extrahepatic and intrahepatic cholangiocarcinoma: A large population-based study

Peng Liao et al. Medicine (Baltimore). .

Abstract

To date, extrahepatic cholangiocarcinoma (ECCA) and intrahepatic cholangiocarcinoma (ICCA) have rarely been compared; therefore, we attempted to learn more about the rates of metastasis and survival in both ICCA and ECCA.Data of patients in the SEER database diagnosed with ICCA or ECCA were extracted to analyse the rate of metastasis and survival. Univariate and multivariate logistic regression analyses were performed to identify the risk factors for metastasis. Propensity score matching (PSM) was used to compare survival rates between ECCA and ICCA.Data from a total of 15,751 patients diagnosed with ICCA or ECCA were extracted to analyse the rate of metastasis. Metastasis was more common in ECCA than ICCA (42.62% vs. 31.46%, P < .05), while ICCA in the T1 stage had a lower rate of metastasis (25.35% vs. 30.61%, P < .05). Age, pathology grade, tumour size, lymph node metastasis and T stage were independent risk factors for metastasis in both ECCA and ICCA. There was an inverse correlation between age and metastasis in both ICCA and ECCA. Moreover, PSM demonstrated that patients with ECCA had a better prognosis than patients with ICCA. Patients with ICCA in the T1 stage had better survival than those with ECCA in the T1 stage.Our study was the first to compare the rates of metastasis and survival between ECCA and ICCA. We observed an inverse association between age and metastasis, that patients with ECCA had a better prognosis than patients with ICCA, and that patients with ECCA in the T1 stage had worse survival than patients with ICCA in the T1 stage.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Heatmap showing the rate of metastasis of patients with ICCA among patients aged 20–39, 40–49, 50–59, 60–69, 70-79 and 80+ years stratified by different characteristics.
Figure 2
Figure 2
Association between odds of metastasis and age at diagnosis in patients with ICCA. The P value for the linear trend of the log odds of lymph node metastasis was tested using score statistics and variance.
Figure 3
Figure 3
Heatmap showing the rate of metastasis in patients with ECCA among patients aged 20–39, 40–49, 50–59, 60–69, 70–79 and 80+ years stratified by different characteristics.
Figure 4
Figure 4
Association between odds of metastasis and age at diagnosis in patients with ECCA. The P value for the linear trend of the log odds of lymph node metastasis was tested using score statistics and variance.
Figure 5
Figure 5
Comparison of OS (A) and CSS (B) among patients diagnosed with ECCA and ICCA.
Figure 6
Figure 6
Comparison of OS (A) and CSS (A) among patients diagnosed with ECCA and ICCA after performing PSM.
Figure 7
Figure 7
Comparison of OS (A) and CSS (B) among patients diagnosed with ECCA and ICCA in the T1 stage.
Figure 8
Figure 8
Comparison of OS (A) and CSS (B) among patients diagnosed with ECCA and ICCA in the T1 stage after performing PSM.
See this image and copyright information in PMC

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