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Review
. 2021 Jan 12;3(1):R35-R47.
doi: 10.1530/VB-20-0013. eCollection 2021.

The aging endothelium

Ka Ka Ting  1 , Paul Coleman  1 , Yang Zhao  1 , Mathew A Vadas  1 , Jennifer R Gamble  1
Affiliations
Review

The aging endothelium

Ka Ka Ting et al. Vasc Biol. .

Abstract

Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.

Keywords: age-related disease; aging; endothelium; senescence; vascular dysfunction.

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Figures

Figure 1
Figure 1
A typical senescent phenotype that is shared between different cell types and activation senescent pathways.
Figure 2
Figure 2
General scheme depicting the structural and functional changes in senescent ECs. Black lines represent tight or adhesion junction interactions between the ECs.
Figure 3
Figure 3
Examples of H2O2-induced senescent phenotype in human umbilical endothelial cells (HUVECs) from our lab. Senescent HUVECs depicted by red asterisk had upregulated (A) SA b-Gal, (B) nuclear p21 expression and reduced (C) VE-cadherin compared to non-senescent ECs (white asterisk).
See this image and copyright information in PMC

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