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. 1988 Jul 15;241(4863):357-9.
doi: 10.1126/science.3388046.

Type-restricted neutralization of molecular clones of human immunodeficiency virus

D J Looney  1 , A G Fisher, S D Putney, J R Rusche, R R Redfield, D S Burke, R C Gallo, F Wong-Staal
Affiliations

Type-restricted neutralization of molecular clones of human immunodeficiency virus

D J Looney et al. Science. .

Abstract

In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such "clonal restriction" of neutralizing activity.

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