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Case Reports
. 2021 Jul;36(7):2558-2561.
doi: 10.1111/jocs.15544. Epub 2021 Apr 21.

Late outcome after surgical and topical treatment for Aspergillus mediastinitis after heart transplantation

Paul R Vogt  1   2 , Raed Aser  2 , Daniel Schmidlin  3 , Paul Mohacsi  4 , Pascal A Berdat  1 , Phillip Went  5 , Markus Flepp  6 , Carlos A Mestres  2
Affiliations
Case Reports

Late outcome after surgical and topical treatment for Aspergillus mediastinitis after heart transplantation

Paul R Vogt et al. J Card Surg. 2021 Jul.

Abstract

The 7-year long-term survival after Aspergillus fumigatus mediastinitis after heart transplantation, an uncommonly described condition, is herein reported. A 66-year-old male developed an infection with A. fumigatus covering the entire thoracic cavity with a fungal turf after orthotopic heart transplantation. Repeated surgical removal of infectious and necrotic tissue together with innovative topical treatment using voriconazole and chlorhexidine combined with systemic antifungal treatment, helped in controlling the infection. Definitive wound closure was achieved by standard sternal refixation and latissimus dorsi muscle flap plasty. Survival after A. fumigatus mediastinitis after heart transplantation was achieved with sequential debridement in combination with topical application of antifungal agents.

Keywords: Aspergillus fumigatus; fungal infection; heart transplant; mediastinitis; mycotic aneurysm; topical treatment.

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References

REFERENCES

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