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. 2021 Sep;85(3):297-306.
doi: 10.1111/cod.13868. Epub 2021 May 11.

Patch test results in patients with suspected contact allergy to shoes: Retrospective IVDK data analysis 2009-2018

Stephan Traidl  1 , Thomas Werfel  1 , Franziska Ruëff  2 , Dagmar Simon  3 , Claudia Lang  4 , Johannes Geier  5 ; IVDK
Collaborators, Affiliations
Free article

Patch test results in patients with suspected contact allergy to shoes: Retrospective IVDK data analysis 2009-2018

Stephan Traidl et al. Contact Dermatitis. 2021 Sep.
Free article

Abstract

Background: Allergic contact dermatitis caused by shoes is common and new relevant allergens have been identified.

Objectives: To investigate the pattern of type IV sensitization in patients with suspected allergic contact dermatitis of the feet related to shoes as a presumed culprit trigger.

Methods: Retrospective analysis of data of the Information Network of Departments of Dermatology (IVDK), 2009-2018.

Results: Six hundred twenty-five patients with presumed shoe dermatitis were identified in a cohort of 119 417 patients. Compared to patients with suspected contact sensitization from other allergen sources (n = 118 792), study group patients were more frequently sensitized to potassium dichromate (10.8% vs 3.5%), colophony (7.2% vs 3.7%), mercaptobenzothiazole (MBT; 4.0% vs 0.6%), mercapto mix (4.6% vs 0.6%), and p-tert-butylphenol formaldehyde resin (1.6% vs 0.5%). Sensitizations to urea formaldehyde resin, melamine formaldehyde resin, glutaraldehyde, tricresyl phosphate, and phenyl glycidylether were rare. Moreover, reactions to compounds in the leather or textile dyes test series were scarce.

Conclusion: A distinct sensitization pattern was observed in patients with suspected allergy to shoe materials. Although substances with low sensitization rates should be removed from the leather and shoe patch test series, novel potential allergens should be added.

Keywords: contact allergy; leather; mercaptobenzothiazole; p-tert-butylphenol formaldehyde resin; patch testing; potassium dichromate; shoe dermatitis.

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References

REFERENCES

    1. Kuttruff JT, DeHart SG, OʼBrien MJ. 7500 years of prehistoric footwear from Arnold Research Cave, Missouri. Science. 1998;281(5373):72-75.
    1. Holden CR, Gawkrodger DJ. 10 years' experience of patch testing with a shoe series in 230 patients: which allergens are important? Contact Dermatitis. 2005;53(1):37-39.
    1. Landeck L, Uter W, John SM. Patch test characteristics of patients referred for suspected contact allergy of the feet-retrospective 10-year cross-sectional study of the IVDK data. Contact Dermatitis. 2012;66(5):271-278.
    1. Shackelford KE, Belsito DV. The etiology of allergic-appearing foot dermatitis: a 5-year retrospective study. J Am Acad Dermatol. 2002;47(5):715-721.
    1. Angelini G, Vena GA, Meneghini CL. Shoe contact dermatitis. Contact Dermatitis. 1980;6(4):279-283.

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