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. 2021 Apr 21;21(1):204.
doi: 10.1186/s12893-021-01173-8.

Short-term recovery in patients suffering hypoparathyroid after thyroidectomy: a case control study

Duntao Su  1 , Fada Xia  1 , Wanze Huang  1 , Zhejia Zhang  1 , Ning Bai  1 , Di Wang  1 , Xin Liao  1 , Xinying Li  2
Affiliations

Short-term recovery in patients suffering hypoparathyroid after thyroidectomy: a case control study

Duntao Su et al. BMC Surg. .

Abstract

Background: Postoperative hypoparathyroidism is the main reason for outpatient follow-up and long-term oral calcium and calcitriol treatment. Our study investigated the influencing factors and powerful predictors of short-term postoperative parathyroid function recovery.

Methods: Logistic regression was used to compare the clinicopathological characteristics; surgical details; and serum calcium (Ca), magnesium (Mg), and phosphorus (P) concentrations of patients. A receiver operating characteristic (ROC) curve was used to analyze the predictors of normal parathyroid hormone (PTH).

Results: Among the 111 patients with PTH < 10 pg/mL on the first postoperative day, most patients experienced a return to normal PTH (PTH > 15 pg/mL) within 30 days postoperatively. Univariate analysis showed that Pod (postoperative day) 1 PTH, Pod3 PTH, Pod7 Ca, Pod7 Mg, and Pod7 P (P < 0.05) were associated with parathyroid function recovery to normal on the seventh postoperative day. Multivariate logistic regression analysis revealed the following independent risk factors for normal PTH levels at Pod7 after thyroidectomy: Pod3 PTH (P = 0.038), Pod1 PTH (P = 0.056), Pod7 Mg (P = 0.001), Pod7 P (P = 0.020), and the number of parathyroid glands in situ intraoperatively. The combined sensitivity of serum magnesium concentration and phosphorus concentration to predict parathyroid function recover to normal on the seventh postoperative day was 82.76%, with a sensitivity of 76.83%.

Conclusion: Serum magnesium, phosphorus and PTH concentrations are important influencing factors and effective predictors of short-term postoperative parathyroid function recovery to normal. Serum ion is an effective auxiliary diagnostic method for hypoparathyroidism after thyroidectomy.

Keywords: Hypocalcemia; Hypoparathyroidism; Thyroidectomy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PTH returns to normal on days 1, 3, 7, and 30 after surgery. Pod postoperative day
Fig. 2
Fig. 2
Changing trend in serum ionized Ca, Mg and P before and after thyroidectomy. Pod postoperative day
Fig. 3
Fig. 3
ROC curves corresponding to serum ion concentrations
See this image and copyright information in PMC

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