Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;110(2):283-291.
doi: 10.1002/JLB.5MR0321-632R. Epub 2021 Apr 22.

The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke

Jinman Chen  1   2   3   4 , Linmei Wang  5 , Hao Xu  1   2   4 , Yongjun Wang  1   2   3   4 , Qianqian Liang  1   2   4
Affiliations
Review

The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke

Jinman Chen et al. J Leukoc Biol. 2021 Aug.

Abstract

The lymphatic drainage system of the central nervous system (CNS) plays an important role in maintaining interstitial fluid balance and regulating immune responses and immune surveillance. The impaired lymphatic drainage system of the CNS might be involved in the onset and progression of various neurodegenerative diseases, neuroinflammation, and cerebrovascular diseases. A significant immune response and brain edema are observed after stroke, resulting from disrupted homeostasis in the brain. Thus, understanding the lymphatic drainage system of the CNS in stroke may lead to the development of new approaches for therapeutic interventions in the future. Here, we review recent evidence implicating the lymphatic drainage system of the CNS in stroke.

Keywords: glymphatic system; immune response; lymphatic drainage system; meningeal lymphatics; neuroinflammation; stroke.

PubMed Disclaimer

References

REFERENCES

    1. Schwager S, Detmar M. Inflammation and lymphatic function. Front Immunol. 2019;10:308.
    1. Breslin JW, Yang Y, Scallan JP, et al. Lymphatic vessel network structure and physiology. Compr Physiol. 2018;9:207-299.
    1. Bucchieri F, Farina F, Zummo G, Cappello F. Lymphatic vessels of the dura mater: a new discovery? J Anat. 2015;227:702-703.
    1. Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-341.
    1. Aspelund A, Antila S, Proulx ST, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212:991-99.

Publication types