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. 2021 Jan 21;55(1):42-49.
doi: 10.2478/raon-2021-0003.

Trends in population-based cancer survival in Slovenia

Vesna Zadnik  1 , Tina Zagar  1 , Katarina Lokar  1 , Sonja Tomsic  1 , Amela Duratovic Konjevic  2 , Branko Zakotnik  1
Affiliations

Trends in population-based cancer survival in Slovenia

Vesna Zadnik et al. Radiol Oncol. .

Abstract

Background: The aim of our study was to describe the survival of Slovenian cancer patients diagnosed in the last twenty years. An insight is given into the improvement made in different cancer types, population groups and prognostic factors.

Materials and methods: The principal data source was the population-based Slovenian Cancer Registry. The survival analysis included patients diagnosed with cancer in twenty years period from 1997 to 2016, which has been divided into four consecutive five-year periods. In addition, the analysis was stratified by cancer type, gender, age and stage. The survival was estimated using net survival calculated by the Pohar-Perme method and the complete approach has been applied.

Results: The survival of Slovenian cancer patients has been increasing over time. During the 20 years observed, five-year net survival increased by 11 percentage points. Significantly higher growth was observed in men. Age and stage at diagnosis are still crucial for the survival of cancer patients. Five-year net survival is lowest in those over 75 years of age at diagnosis but has also improved by seven percentage points over the past 20 years. The five-year net survival of patients in the localized stage increased by ten percentage points over the 20 years under observation. Survival of patients in the distant stage has not been improving. In both sexes, survival for melanoma, colorectal and lung cancers have increased significantly over the last 20 years. Progress has also been made in the two most common gender specific cancers: breast cancer in women and prostate cancer in men. Still, the significant progress in prostate cancer is probably mostly due to lead-time bias as during the study period, Slovenia used indiscriminate PSA testing, which probably artificially prolonged survival.

Conclusions: The survival of Slovenian cancer patients has been increasing over time, which gives us a basis and an incentive for future improvements. To monitor the effectiveness of managing the cancer epidemic, the cancer burden needs to be monitored also in the future, using quality data and scientifically justified methodological approaches. In this process a well organised population-based cancer registries should play a key role.

Keywords: Cancer Registry; Slovenian; cancer burden; cancer survival; time trend.

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Figures

Figure 1
Figure 1
Five-year net survival (with a 95% confidence interval) of adult patients (20–94 years) with selected cancers, Slovenia 1997–2001 and 2012–2016.
Figure 2
Figure 2
Five-year net survival of patients with cancer (all sites but non-melanoma skin cancer) by age group, Slovenia 1997–2016.
Figure 3
Figure 3
Five-year net survival of patients with cancer (all solid tumours but non-melanoma skin cancer) by stage at diagnosis, Slovenia 1997–2016.
See this image and copyright information in PMC

References

    1. Zadnik V, Primic Žakelj M, Lokar K, Jarm K, Ivanuš U. Cancer burden in Slovenia with the time trends analysis. Radiol Oncol. 2017;22:47–55. doi: 10.1515/raon-2017-0008. Žagar T. - DOI - PMC - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics. GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Coleman MP, Alexe D, Albreht T, McKee M. Responding to the challenge of cancer in Europe. Ljubljana: Institute of Public Health of the Republic of Slovenia;; 2008.
    1. Primic-Žakelj M. Žagar T, Zakotnik B. [Survival of cancer patients, diagnosed in 1991–2005 in Slovenia.]. [Slovenian and English] Zadnik V: Ljubljana: Instititute of Occology Ljubljana;; 2009.
    1. Zadnik V, Žagar T, Lokar K, Tomšič S, Duratović-Konjević A, Zakotnik B. [Survival of cancer patients, diagnosed in 1997–2016 in Slovenia.]. [Slovenian and English] Ljubljana: Instititute of Oncology Ljubljana;; 2021. in press.