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Review
. 2021 Apr 22;22(6):31.
doi: 10.1007/s11934-021-01050-0.

Biomarkers for Renal Cell Carcinoma Recurrence: State of the Art

Michele Marchioni  1   2 , Juan Gomez Rivas  3 , Anamaria Autran  4 , Moises Socarras  5 , Simone Albisinni  6 , Matteo Ferro  7 , Luigi Schips  8 , Roberto Mario Scarpa  9 , Rocco Papalia  9 , Francesco Esperto  9
Affiliations
Review

Biomarkers for Renal Cell Carcinoma Recurrence: State of the Art

Michele Marchioni et al. Curr Urol Rep. .

Abstract

Purpose of review: We aim to summarize the current state of art about the possible use of biomarkers for predicting renal cell carcinoma (RCC) recurrence after curative treatment. In addition, we aim to provide a snapshot about the clinical implication of biomarkers use for follow-up planification.

Recent findings: A wide variety of biomarkers have been proposed. RCC biomarkers have been individuated in tumoral tissue, blood, and urine. A variety of molecules, including proteins, DNA, and RNA, warrant a good accuracy for RCC recurrence and progression prediction. Their use in prediction models might warrant a better patients' risk stratification. Future prognostic models will probably include a combination of classical features (tumor grade, stage, etc.) and novel biomarkers. Such models might allow a more accurate treatment and follow-up planification.

Keywords: Biomarkers; Liquid biopsy; Renal cell carcinoma; miRNA.

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Conflict of interest statement

The authors declare no competing interests.

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