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Review
. 2021 Apr 22;17(4):e1009384.
doi: 10.1371/journal.ppat.1009384. eCollection 2021 Apr.

Actives from MMV Open Access Boxes? A suggested way forward

Kirandeep Samby  1 , Paul A Willis  1 , Jeremy N Burrows  1 , Benoît Laleu  1 , Peter J H Webborn  2
Affiliations
Review

Actives from MMV Open Access Boxes? A suggested way forward

Kirandeep Samby et al. PLoS Pathog. .

Abstract

It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of "Open Access Boxes" is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Suggested screening cascade of compounds from MMV Open Boxes.
MMV, Medicines for Malaria Venture.
See this image and copyright information in PMC

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