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. 2021 Apr 16:76:e2474.
doi: 10.6061/clinics/2021/e2474. eCollection 2021.

Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features

Anderson Alves de Camargo  1 , Rejane Agnelo Silva de Castro  1 , Rodolfo P Vieira  2   3 , Manoel Carneiro Oliveira-Júnior  1 , Amanda Aparecida de Araujo  1 , Kátia De Angelis  1   4 , Samia Zahi Rached  5 , Rodrigo Abensur Athanazio  5 , Rafael Stelmach  5 , Simone Dal Corso  1
Affiliations

Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features

Anderson Alves de Camargo et al. Clinics (Sao Paulo). .

Abstract

Objectives: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity.

Methods: This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52.5±25.6%) and 42 healthy controls (age: 44±17 years, FEV1: 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured.

Results: Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1β, IL-6, and tumor necrosis factor-α correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity.

Conclusions: Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity.

Trial registration: ClinicalTrials.gov NCT02208830.

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Conflict of interest statement

No potential conflict of interest was reported.

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