MK reports grants and personal fees from Bristol Myers Squibb/Celgene, personal fees and travel support from Amgen, Janssen, and Takeda, and personal fees from AbbVie, GSK, Karyopharm, and Seattle Genetics, outside the submitted work. CPaw reports personal fees and non-financial support from Amgen, Celgene, Janssen, and Sanofi, and non-financial support from Oncopeptides, outside the submitted work. KB reports personal fees from Celgene, GlaxoSmithKline, Janssen, and Takeda, outside the submitted work. All other authors declare no conflicts of interest. We thank David Cairns for providing statistical advice. We acknowledge National Health Service funding to the National Institute for Health Research (NIHR) Biomedical Research Centre at The Royal Marsden and the Institute of Cancer Research (ICR). SB is a Wellcome Trust Clinical Research Fellow, AS is an NIHR and ICR Clinical Lecturer, and CPaw is a Cancer Research UK Clinician Scientist.