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. 2021 Mar-Apr;25(2):144-149.
doi: 10.4103/jisp.jisp_58_20. Epub 2021 Mar 1.

Evaluation of Morinda citrifolia (noni) fruit extract as a bone regenerative material in the treatment of periodontal intrabony osseous defects: Clinical and cone-beam computed tomography assessment

Blessy Shin Sabu  1 , Kabbur Thippanna Chandrashekar  1 , Rohit Mishra  1 , Vandana Dubey Tripathi  1 , Honey Khatri  1 , Ankita Deo  1
Affiliations

Evaluation of Morinda citrifolia (noni) fruit extract as a bone regenerative material in the treatment of periodontal intrabony osseous defects: Clinical and cone-beam computed tomography assessment

Blessy Shin Sabu et al. J Indian Soc Periodontol. 2021 Mar-Apr.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] J Indian Soc Periodontol. 2021 May-Jun;25(3):270. doi: 10.4103/0972-124X.315467. J Indian Soc Periodontol. 2021. PMID: 34158698 Free PMC article.

Abstract

Background: Nature and its products can be utilized for regeneration in periodontal destruction and damage to supporting tissues. We come across the use of various graft materials to reestablish the lost bone and for the long-term survival of teeth. The objective of this study was to evaluate the bone fill efficacy of Morinda citrifolia fruit extract in the periodontal bone defect.

Materials and methods: This randomized study included twenty patients indicated for periodontal regenerative therapy and were equally divided and assigned into the experimental and control group. Open flap debridement alone was performed in the control group, while placement of extract along with open flap debridement was done in the experimental group. Clinical parameters assessed were gingival index, probing pocket depth, and relative attachment level, and the amount of bone fill was assessed using cone-beam computed tomography (CBCT) at baseline and at 6-month interval.

Results: From the values of clinical parameters, there was a mean reduction in probing pocket and gain in attachment level and a 27.7% increase in bone fill in experimental group as compared to the control group from CBCT analysis.

Conclusions: The use of M. citrifolia fruit extract in the intraosseous defect was found to be efficacious in terms of relative attachment level and the amount of bone fill, and it had shown some anti-inflammatory affect.

Keywords: Cone beam computed tomography; Morinda citrifolia; intraosseous defect; periodontal regeneration.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Intra-osseous defect after flap reflection
Figure 2
Figure 2
Placement of Morinda citrifolia fruit extract
Figure 3
Figure 3
Flap reflection with intra-osseous defect in control group
Figure 4
Figure 4
Morinda citrifolia fruit extract in powder form
Graph 1
Graph 1
Probing pocket depth scores in control group and experimental group at baseline and 6 months
Graph 2
Graph 2
Comparison of relative attachment level in control group and experimental group at different time intervals
Figure 5
Figure 5
Pre-cone-beam computed tomography showing intraosseous defect in axial, coronal, and three-dimensional view
Figure 6
Figure 6
Post-cone-beam computed tomography showing intraosseous defect in axial, coronal, and three-dimensional view
Graph 3
Graph 3
Mean percentage change in cone-beam computed tomography assessment in control group and experimental group at different time intervals
Figure 7
Figure 7
Pre-cone-beam computed tomography showing intraosseous defect in axial, coronal, and three-dimensional in the experimental group
Figure 8
Figure 8
Post-cone-beam computed tomography showing intraosseous defect in axial, coronal, and three-dimensional view in the experimental group
See this image and copyright information in PMC

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