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. 2020 Nov 30;12(4):202-207.
doi: 10.4103/jgid.jgid_145_19. eCollection 2020 Oct-Dec.

Incidence, Risk Factors and Clinical Outcomes of Patients with Hypermucoviscoid Klebsiella in a Tertiary Intensive Care Unit

Vimal Bhardwaj  1 , Vellaichamy Muthupandi Annapandian  2 , Annie Rofeena Sinazer  3 , Arjun Alva  1 , Shiva Prasad  1
Affiliations

Incidence, Risk Factors and Clinical Outcomes of Patients with Hypermucoviscoid Klebsiella in a Tertiary Intensive Care Unit

Vimal Bhardwaj et al. J Glob Infect Dis. .

Abstract

Background and objectives: Hypermucoviscoid Klebsiella(hvKP), a dreaded variant of Klebsiella, so far, fewer cases were reported from the community. This study was designed to evaluate the incidence of hvKP isolates, risk factors for hvKP infections, antibiotic sensitivity pattern and clinical outcome including morbidity and mortality.

Patients and setting: Patients who have got admitted under medical intensive care unit (MICU) and had positive culture of Klebsiella infections.

Materials and methods: This study was conducted at department of MICU at a tertiary care hospital between January 2018 and December 2018. A standardized proforma was prepared and data was collected, which includes basic demographics of the patients, co-morbidities, clinical details and mortality. This study was approved by the Institutional Review Board and Ethics Committee.

Results: A total of 165 patients (males, 123; 74.5%) had Klebsiella pneumoniae infection during the study period, out of whom 32 was hvKP (19.4%). The mean age was 53.1 ± 16.8 years. Among the 32 hvKP patients, 22 (68.8%) were hospital acquired infection (HAI) and 10 were (31.2%) community acquired infection. The overall mortality rate of hvKP infection was 56.2% (18/32). The incidence of mortality rate was similar in patients having pan-drug sensitive and in patients with extreme drug-resistance (61.9% vs. 66.7%; P = 0.831). HAI is significantly associated with multi drug resistance of hvKP (odds ratio [OR], 7.917; P < 0.05) and diabetes is associated with increased risk of hvKP related mortality (OR, 5.250; P = 0.054).

Conclusions: Our study results showed, increased incidence of HAI with hvKP predominantly associated with pneumonia and increase in trend of drug resistance with two cases being pan resistant. More number of studies are required to evaluate the existing antibiotics strategy and steps to curb the spread of this dreaded infection.

Keywords: Community acquired infection; Klebsiella; hospital acquired infection; hvKP; hypermucoviscoid Klebsiella.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Depiction of (a) classical Klebsiella pneumoniae and (b) hypermucoviscoid Klebsiella on the agar plate
Figure 2
Figure 2
String test showing the length of string >5 mm in hypermucoviscoid klebsiella
See this image and copyright information in PMC

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