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. 2021 Apr 6:8:648727.
doi: 10.3389/fmed.2021.648727. eCollection 2021.

Frequency of Systemic Lupus Erythematosus Was Decreasing Among Hospitalized Patients From 2013 to 2017 in a National Database in China

Ying Tan  1   2   3   4   5 , Feng Yu  1   2   3   4   5   6 , Jianyan Long  7 , Lanxia Gan  7 , Haibo Wang  7 , Luxia Zhang  1   2   3   4   5   8 , Minghui Zhao  1   2   3   4   5   9
Affiliations

Frequency of Systemic Lupus Erythematosus Was Decreasing Among Hospitalized Patients From 2013 to 2017 in a National Database in China

Ying Tan et al. Front Med (Lausanne). .

Abstract

Backgrounds: Limited data was reported for the frequency of SLE in China. The aim of this study was to investigate the frequency, geographical, and ethnic distributions of hospitalized SLE patients with data from the Hospital Quality Monitoring System (HQMS) in China. Methods: Hospitalized patients were investigated from a national inpatient database covering 46.0% of tertiary hospitals in China from 2013 to 2017. Data regarding the diagnosis of SLE were extracted based on ICD-10 codes. We collected and analyzed data from the front page of the records of inpatients, including frequency, demographic characteristics, and geographic distributions of SLE. Results: Among 158.3 million inpatients attended during the study period, 0.31% (491, 225) were diagnosed with SLE. The frequency of SLE decreased during the study period (from 0.30% in 2013 to 0.27% in 2017). The frequency of SLE increased with latitude (0.21% in northern China and 0.39% in southern China in 2017). Hospitalizations mostly occurred in winter (31.24%). The Li population had the highest frequency of patients with SLE (0.76%). The all-cause in-hospital mortality rate of SLE decreased from 0.74% (255/34,746) in 2013 to 0.54% (295/54,168) in 2017. The percentage of SLE patients with infections increased from 3.14% in 2013 to 4.72% in 2017. The percentage of SLE patients with tumors and thrombosis also increased slightly from 0.85 and 1.43% in 2013 to 1.27 and 2.45% in 2017, respectively. Conclusion: This study provided epidemiological information of SLE in hospitalized patients in China for the first time. An ethnic and spatial clustering trend of SLE was observed.

Keywords: frequency; hospitalized population; lupus nephritis; mortality; systemic lupus erythaematosus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The decreasing trend in SLE in China from 2013 to 2017. The columns indicate the numbers of patients with SLE; the line shows the percentage of SLE or lupus in HQMS.
Figure 2
Figure 2
The ethnic distribution of SLE in China in 2017. The Li, Dai and Zhuang minorities had the higher frequencies of SLE, with frequencies of 0.755, 0.576, and 0.48%, respectively. HQMS, Hospital Quality Monitoring System Note: Information on races was missing for 11,648 (4.62%) of all 5-year SLE patients included.
Figure 3
Figure 3
The frequency of SLE among all the patients in HQMS in province of China in 2017. The frequency of SLE was much higher in Guangxi Province, Hainan Province and Guangdong Province (0.46, 0.41, and 0.36%, respectively).
See this image and copyright information in PMC

References

    1. Ruiz-Irastorza G, Khamashta MA, Castellino G, Hughes GR. Systemic lupus erythematosus. Lancet. (2001) 357:1027–32. 10.1016/S0140-6736(00)04239-2 - DOI - PubMed
    1. Tselios K, Gladman DD, Sheane BJ, Su J, Urowitz M. All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971–2013). Ann Rheum Dis. (2019) 78:802–806. 10.1136/annrheumdis-2018-214802 - DOI - PubMed
    1. Zhu TY, Tam LS, Li EK. The socioeconomic burden of systemic lupus erythematosus: state-of-the-art and prospects. Exp Rev Pharmacoeconomics Outcomes Res. (2012) 12:53–69. 10.1586/erp.11.92 - DOI - PubMed
    1. Almaani S, Meara A, Rovin BH. Update on lupus nephritis. Clin J Am Soc Nephrol. (2017) 12:825–35. 10.2215/CJN.05780616 - DOI - PMC - PubMed
    1. McCarty DJ, Manzi S, Medsger TA, Ramsey-Goldman R, LaPorte RE, Kwoh CK. Incidence of systemic lupus erythematosus. Race and gender differences. Arthrit Rheumatism. (1995) 38:1260–70. 10.1002/art.1780380914 - DOI - PubMed

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